Coagulation Factor XIV/Protein C Antibody [Biotin] Summary
Immunogen |
Chinese hamster ovary cell line CHO-derived recombinant mouse Coagulation Factor XIV/Protein C Ile19-Leu460 Accession # P33587 |
Specificity |
Detects mouse Coagulation Factor XIV/Protein C in Western blots. In Western blots, approximately 15% cross-reactivity with recombinant human Coagulation Factor XIV/Protein C is observed. |
Source |
N/A |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Sheep |
Gene |
PROC |
Purity Statement |
Antigen Affinity-purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
Preservative |
No Preservative |
Concentration |
LYOPH |
Reconstitution Instructions |
Reconstitute at 0.2 mg/mL in sterile PBS. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Coagulation Factor XIV/Protein C Antibody [Biotin]
Background
Protein C is a vitamin K-dependent serine protease synthesized in the liver as a single-chain precursor, which is then proteolytically processed to two disulfide-linked chains (1). The light chain consists of a Gla (gamma-carboxy-glutamate) domain and two EGF-like domains. The heavy chain consists of an activation peptide (aa 199‑212) and serine protease domain (aa 213‑449). Physiologically, Protein C is converted to the active form by thrombin, which releases the activation peptide. Protein C plays a key role in anticoagulation, cleaving factors VIIIa and Va to inactivate them. This anticoagulation activity can be enhanced by a presence of a cofactor such as protein S. In hereditary thrombophilia, Protein C deficiency is caused by a genetic mutation that affects Protein C activity. A severe recessive form may result in massive thrombosis fatal to patient.
- Shen, L. and Dahlbäck, B. (2004) in Handbook of Proteolytic Enzymes, Barrett, A.J. et al. eds. pp.
1673.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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