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Coagulation Factor III/Tissue Factor Antibody [Phycoerythrin]

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RAW 264.7 mouse monocyte/macrophage cell line treated with LPS was stained with Goat Anti-Mouse Coagulation Factor III/Tissue Factor PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB3178P, ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clonality
Polyclonal
Host
Goat
Conjugate
Phycoerythrin

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Coagulation Factor III/Tissue Factor Antibody [Phycoerythrin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Coagulation Factor III/Tissue Factor
Ala29-Glu251
Accession # P20352
Specificity
Detects mouse Coagulation Factor III in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 5% cross‑reactivity with recombinant human Coagulation Factor III is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
F3
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
FAB3178P in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Coagulation Factor III/Tissue Factor Antibody [Phycoerythrin]

  • CD142 antigen
  • CD142
  • coagulation factor III (thromboplastin, tissue factor)
  • Coagulation Factor III
  • F3
  • FLJ17960
  • TF
  • TFA
  • Thromboplastin
  • Tissue Factor

Background

Coagulation Factor III/Tissue Factor (TF), also known as thromboplastin and CD142, is an integral membrane protein found in a variety of cell types. It functions as a protein cofactor/receptor of Coagulation Factor VII, which is synthesized in the liver and circulated in the plasma (1). Upon binding of TF, the inactive factor VII is rapidly converted into activated VIIa. The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and has also important coagulation-independent functions such as angiognesis (2). Synthesized as a 294 amino acid precursor, mouse TF consists of a signal peptide (residues 1-28) and the mature chain (residues 29-294). As a type I membrane protein, it contains a transmembrane region (residues 252-274) and a cytoplasmic tail (residues 275-294) (3, 4). The purified rmTF corresponds to the ectodomain (residues 29-251) and is potent in activating thermolysin-processed rmCoagulation Factor VII (R&D Systems, Catalog # 3305-SE) under the conditions described in the Activity Assay Protocol.

  1. Morrissey, J.H. (2004) in Handbook of Proteolytic Enzymes. Barrett, A.J. et al. (ed) Academic Press, San Diego, p. 1659. 
  2. Versteeg, H.H. et al. (2003) Carcinogenesis 24:1009.
  3. Ranganathan, G. et al. (1991) J. Biol. Chem. 266:496.
  4. Hartzell, S. (1989) Mol. Cell. Biol. 9:2567.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Coagulation Factor III/Tissue Factor Antibody (FAB3178P)(6)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.


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Flow Cytometry
(4)
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Mouse
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Showing Publications 1 - 6 of 6.
Publications using FAB3178P Applications Species
Magda Zachara, Pernille Y Rainer, Horia Hashimi, Julie M Russeil, Daniel Alpern, Radiana Ferrero et al. Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non‐ and anti‐adipogenic in age‐dependent manner The EMBO Journal 2022-09-15 [PMID: 35996853]
X Chen, Y Lao, J Yi, J Yang, S He, Y Chen SENP3 in monocytes/macrophages up-regulates tissue factor and mediates lipopolysaccharide-induced acute lung injury by enhancing JNK phosphorylation J. Cell. Mol. Med., 2020-03-31;0(0):. 2020-03-31 [PMID: 32237051] (Flow Cytometry, Mouse) Flow Cytometry Mouse
PJ Hohensinne, J Mayer, J Kichbacher, J Kral-Point, B Thaler, C Kaun, L Hell, P Haider, M Mussbacher, JA Schmid, S Stojkovic, S Demyanets, MB Fischer, K Huber, K Wöran, C Hengstenbe, WS Speidl, R Oehler, I Pabinger, J Wojta Alternative activation of human macrophages enhances tissue factor expression and production of extracellular vesicles Haematologica, 2021-02-01;0(0):. 2021-02-01 [PMID: 31974204] (Flow Cytometry, Mouse) Flow Cytometry Mouse
John Eppensteiner, Jean Kwun, Uwe Scheuermann, Andrew Barbas, Alexander T. Limkakeng, Maggie Kuchibhatla et al. Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness JCI Insight 2019-08-22 [PMID: 31434802]
B Hoesel, M Mussbacher, B Dikorman, M Salzmann, A Assinger, L Hell, J Thaler, J Basílio, B Moser, U Resch, H Paar, N Mackman, JA Schmid Androgen receptor dampens tissue factor expression via NF-?B and EGR1 J. Thromb. Haemost., 2018-03-13;0(0):. 2018-03-13 [PMID: 29427323] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Q Zhang, H Wang, H Li, J Xu, K Tian, J Yang, Z Lu, J Zheng Chimeric antigen receptor-modified T Cells inhibit the growth and metastases of established tissue factor-positive tumors in NOG mice Oncotarget, 2017-02-07;8(6):9488-9499. 2017-02-07 [PMID: 28055955] (Flow Cytometry, Mouse) Flow Cytometry Mouse

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FAQs for Coagulation Factor III/Tissue Factor Antibody (FAB3178P). (Showing 1 - 1 of 1 FAQs).

  1. Have you tested any of your anti-tissue factor antibodies against pig? I need one for western blot.
    • Unfortunately, none of our Tissue Factor antibodies have yet been tested with pig samples, so we cannot guarantee that any of them will work in pig. Here is a link to Tissue Factor antibodies that have been validated for use in Western blot. If you are interested in testing any of these antibodies against pig samples, you could become eligible for our Innovator's Reward program.
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Bioinformatics

Gene Symbol F3
Uniprot