CLOCK Antibody (OTI2H7)

Circadian Locomotor Output Cycles Kaput (CLOCK) is a bHLH/PAS protein that plays an important role in the molecular clock mechanism. Specifically, CLOCK activates the central circadian loop by stimulating expression of Period and Timeless proteins. CLOCK has also been shown to interact strongly with other bHLH-PAS proteins such as MOP3, a BMAL1 isoform.

CLOCK levels peak during the late night and the early part of the subjective day. Mutations in CLOCK causes defective transcriptional activity and lengthens the circadian period, leading to abnormal circadian behavior.

CLOCK antibodies are useful tools for research on circadian rythmns, sleep biology and hormonal cycles.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publication 1 - 1 of 1.

Publication using NBP2-46311	Applications	Species
He M, Li L, Li J et al. rs2253820 Variant Controls Blood Pressure Dip After Stroke by Increasing CLOCK-BMAL1 Expression Translational stroke research 2022-07-23 [PMID: 35870088] (IHC-P, WB, Rat)	IHC-P, WB	Rat

Array NBP2-46311

• CLOCK Antibodies
• CLOCK ELISA Kits
• CLOCK Lysate
• CLOCK Proteins