Antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CIITA. The immunogen is located within amino acids 120 - 170 of CIITA. Amino Acid Squence: AEVCQSQRRPFPEEL
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CIITA
Purity
Peptide affinity purified
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125 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified
Alternate Names for CIITA Antibody - BSA Free
C2TA
C2TAMHC class II transactivator type III
CIITAIV
class II, major histocompatibility complex, transactivator
MHC class II transactivator
MHC2TANLR family, acid domain containing
NLRA
nucleotide-binding oligomerization domain, leucine rich repeat and acid domaincontaining
Background
The transactivator CIITA regulates basal and interferon-induced expression of Major Histocompatibility Complex class II genes. CIITA restores expression of all MHC class II gene expression in mutant cells and corrects regulatory defects of MHC class II genes. Antibodies to this transactivator are useful in the study of diseases of pathological MHC class II expression. Antigen can be obtained from Raji cell lysates. Typically levels of CIITA expression are too low to detect endogenous levels of protein expression. Transiently transfected cells are usually employed to study this transcription factor.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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