Chk2 Antibody (4B7)

This product is produced by and distributed for Abnova, a company based in Taiwan.

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 3 of 3.

Publications using H00011200-M01	Applications	Species
Chan YL, Liao CL, Lin YL. Human Kinase/Phosphatase-Wide RNAi Screening Identified Checkpoint Kinase 2 as a Cellular Factor Facilitating Japanese Encephalitis Virus Infection. Front Cell Infect Microbiol 2018-05-17 [PMID: 29868498]
Onul A, Colvard MD, Paradise WA et al. Application of Immunohistochemical Staining to Detect Antigen Destruction as a Measure of Tissue Damage J Histochem Cytochem 2012-08-03 [PMID: 22723525] (IF/IHC, Human)	IF/IHC	Human
Tarjan G, Haines GK 3rd, Vesper BJ et al. Part II Initial molecular and cellular characterization of high nitric oxide-adapted human tongue squamous cell carcinoma cell lines Tumour Biol 2011-02-01 [PMID: 20963646] (WB, Human)	WB	Human

Array H00011200-M01

• Chk2 Antibodies
• Chk2 Lysates
• Chk2 Proteins
• Chk2 ELISA
• Chk2 Proteins and Enzyme