Chk2 Products

Description

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	11200 Human 114212 Rat 50883 Mouse
Uniprot	AAH04207 Human AAH04207.1 Human NM_007194 Human NP_001005735 Human NP_009125.1 Human O96017 Human
Product By Gene ID	11200
Alternate Names	CHK2 checkpoint homolog (S. pombe) EC 2.7.11 EC 2.7.11.1 S.pombe) homolog

Research Areas for Chk2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
Core ESC-Like Genes
DNA Double Strand Break Repair
DNA Repair
Phospho-Specific
Stem Cell Markers