Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD47 APC-conjugated Monoclonal Antibody (Catalog # FAB4670A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View ...read more
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CD47 Antibody (472603) [Allophycocyanin]
antigen identified by monoclonal 1D8
Antigenic surface determinant protein OA3
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
CD47 antigen
CD47 glycoprotein
CD47 molecule
CD47
IAP
IAPintegrin associated protein
Integrin-associated protein
leukocyte surface antigen CD47
MER6
MER6integrin-associated signal transducer
OA3
Protein MER6
Rh-related antigen
Background
CD47, also known as Integrin-associated Protein (IAP), is a ubiquitous 50 kDa multipass transmembrane protein with a single V-type Ig-like domain at its N-terminus. CD47 binding to SIRP alpha prevents the phagocytic engulfment of viable cells. It also binds to VEGFR2, inducing VEGFR2 signaling in both T cells and endothelial cells. Thrombospondin interaction with CD47 on T cells reduces T cell proliferation and inflammatory reactions. Alternative splicing generates isoforms with truncated cytoplasmic domains. Within the N-terminal ECD, human CD47 shares 63% aa sequence identity with mouse and rat CD47.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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