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CCR5 Antibody (CTC8) [Unconjugated]

 (8 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clone
CTC8
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB1801-SP
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CCR5 Antibody (CTC8) [Unconjugated] Summary

Immunogen
CHO Chinese hamster ovary cell line transfected with human CCR5
Specificity
Detects human CCR5 in direct ELISAs and Western blots. For additional information regarding epitope specificity for this antibody and other R&D Systems anti-human CCR5 antibodies, see reference 1 below.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CCR5
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB1801 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CCR5 Antibody (CTC8) [Unconjugated]

  • C-C CKR-5
  • C-C motif chemokine receptor 5 A159A
  • CCCKR5
  • CC-CKR-5FLJ78003
  • CCR5
  • CCR-5
  • CD195 antigen
  • CD195
  • chemokine (C-C motif) receptor 5
  • chemokine receptor CCR5
  • chemr13
  • CKR5
  • CKR-5
  • HIV-1 fusion coreceptor
  • IDDM22CMKBR5C-C chemokine receptor type 5

Background

CCR5 is a G protein-linked seven transmembrane domain chemokine receptor. CCR5 serves as a receptor for several chemokines including MIP-1 alpha , MIP-1 beta , MCP-2, and RANTES. It also functions as a co‑receptor for Macrophage Tropic HIV-1 infection.
  1. Lee, B. et al. (1999) J. Biol. Chem. 274:9617.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CCR5 Antibody (MAB1801)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: ELISA Development, Flow Cytometry, ICC, Western Blot.


Filter By Application
ELISA Development
(1)
Flow Cytometry
(3)
ICC
(2)
Western Blot
(1)
All Applications
Filter By Species
Human
(5)
All Species
Showing Publications 1 - 8 of 8.
Publications using MAB1801 Applications Species
M Weichseldo, Y Tagaya, M Reitz, AL DeVico, OS Latinovic Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies Journal of Translational Medicine, 2022-01-24;20(1):39. 2022-01-24 [PMID: 35073923] (ICC, Human) ICC Human
Shengli Song, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, Garnett Kelsoe A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines Communications Biology 11/25/2021 [PMID: 34824350]
Chain B, Arnold J, Akthar S, Brandt M, Davis D, Noursadeghi M, Lapp T, Ji C, Sankuratri S, Zhang Y, Govada L, Saridakis E, Chayen N A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody. PLoS ONE, 2015-06-01;10(6):e0128381. 2015-06-01 [PMID: 26030924] (ELISA Development, Flow Cytometry, Human) ELISA Development, Flow Cytometry Human
James M. Fox, Richard Kasprowicz, Oliver Hartley, Nathalie Signoret CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells Journal of Leukocyte Biology 7/1/2015 [PMID: 25957306]
Nakano Y, Monde K, Terasawa H, Yuan Y, Yusa K, Harada S, Maeda Y Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1. Virology, 2014-01-31;452(0):117-24. 2014-01-31 [PMID: 24606688] (Flow Cytometry, Human) Flow Cytometry Human
Swaminathan G, Rossi F, Sierra L, Gupta A, Navas-Martin S, Martin-Garcia J A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages. PLoS Pathog, 2012-09-20;8(9):e1002937. 2012-09-20 [PMID: 23028330] (ICC, Human) ICC Human
Tilton J, Wilen C, Didigu C, Sinha R, Harrison J, Agrawal-Gamse C, Henning E, Bushman F, Martin J, Deeks S, Doms R A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5. J Virol, 2010-08-11;84(20):10863-76. 2010-08-11 [PMID: 20702642]
Ottonello L, Montecucco F, Bertolotto M, Arduino N, Mancini M, Corcione A, Pistoia V, Dallegri F CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2. Cell. Signal., 2005-03-01;17(3):355-63. 2005-03-01 [PMID: 15567066] (Flow Cytometry, Western Blot, Human) Flow Cytometry, Western Blot Human

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Bioinformatics

Gene Symbol CCR5