Name: CCR5 Antibody (45523) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB181
Price: 469 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	IHC
Clone	45523
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	NS0 mouse myeloma cell line transfected with human CCR5 Met1-Leu352 Accession # P51681
Specificity	Can be used to detect CCR5 present on stimulated human PBMCs only after cells are fixed with 2% formaldehyde. It does not detect CCR5 on unfixed human PBMCs. It does not cross-react with CCR1, CCR2, or CCR3. For additional information regarding epitope specificity for this antibody and other R&D Systems anti-human CCR5 antibodies, see Lee, B. et al., 1999, J. Biol. Chem. 274:9617.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Mouse
Gene	CCR5
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB181	Applications	Species
Zhu, R;Sang, X;Zhou, J;Meng, Q;Huang, LSM;Xu, Y;An, J;Huang, Z; CXCR4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120 Viruses 2023-04-28 [PMID: 37243169] (Bioassay, Chinese Hamster)	Bioassay	Chinese Hamster
M Weichseldo, Y Tagaya, M Reitz, AL DeVico, OS Latinovic Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies Journal of Translational Medicine, 2022-01-24;20(1):39. 2022-01-24 [PMID: 35073923] (ICC, Human)	ICC	Human
Shengli Song, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, Garnett Kelsoe A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines Communications Biology 11/25/2021 [PMID: 34824350]
Sharon M. Anderson, Andrea R. Thurman, Neelima Chandra, Suzanne S. Jackson, Susana Asin, Christiane Rollenhagen et al. Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women Nutrients 10/17/2020 [PMID: 33080839]
G Nishikawa, K Kawada, J Nakagawa, K Toda, R Ogawa, S Inamoto, R Mizuno, Y Itatani, Y Sakai Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5 Cell Death Dis, 2019-03-19;10(4):264. 2019-03-19 [PMID: 30890699] (IHC-P, Xenograft)	IHC-P	Xenograft
Sensen Lin, Li Sun, Xiaodan Lyu, Xiongfei Ai, Danyu Du, Nan Su et al. Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop Oncotarget 12/15/2017 [PMID: 29299159]
James M. Fox, Richard Kasprowicz, Oliver Hartley, Nathalie Signoret CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells Journal of Leukocyte Biology 7/1/2015 [PMID: 25957306]
Yoshida N, Nishikori M, Izumi T, Imaizumi Y, Sawayama Y, Niino D, Tashima M, Hoshi S, Ohshima K, Shimoyama M, Seto M, Tsukasaki K Primary peripheral T-cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis. Br J Haematol, 2013-02-21;161(2):214-23. 2013-02-21 [PMID: 23432459] (IHC, Human)	IHC	Human
Alonzo , Francis, Kozhaya , Lina, Rawlings , Stephen, Reyes-Robles , Tamara, DuMont , Ashley L, Myszka , David G, Landau , Nathanie, Unutmaz , Derya, Torres , Victor J CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature, 2012-12-12;493(7430):51-5. 2012-12-12 [PMID: 23235831] (Bioassay, Human)	Bioassay	Human
Weigt SS, Elashoff RM, Keane MP, Strieter RM, Gomperts BN, Xue YY, Ardehali A, Gregson AL, Kubak B, Fishbein MC, Saggar R, Ross DJ, Lynch JP, Zisman DA, Belperio JA Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Am. J. Transplant., 2008-07-01;8(7):1512-22. 2008-07-01 [PMID: 18513272] (IHC-P, Human)	IHC-P	Human
Roulet V, Satie AP, Ruffault A, Le Tortorec A, Denis H, Guist'hau O, Patard JJ, Rioux-Leclerq N, Gicquel J, Jegou B, Dejucq-Rainsford N Susceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro. Am. J. Pathol., 2006-12-01;169(6):2094-103. 2006-12-01 [PMID: 17148672] (ICC, Human)	ICC	Human
Deiva K, Khiati A, Hery C, Salim H, Leclerc P, Horellou P, Tardieu M CCR5-, DC-SIGN-dependent endocytosis and delayed reverse transcription after human immunodeficiency virus type 1 infection in human astrocytes. AIDS Res. Hum. Retroviruses, 2006-11-01;22(11):1152-61. 2006-11-01 [PMID: 17147503] (Neutralization, Human)	Neutralization	Human
Capelli A, Di Stefano A, Gnemmi I, Donner CF CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis. Eur. Respir. J., 2005-04-01;25(4):701-7. 2005-04-01 [PMID: 15802346] (Flow Cytometry, Human)	Flow Cytometry	Human
Ottonello L, Montecucco F, Bertolotto M, Arduino N, Mancini M, Corcione A, Pistoia V, Dallegri F CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2. Cell. Signal., 2005-03-01;17(3):355-63. 2005-03-01 [PMID: 15567066] (Flow Cytometry, Human)	Flow Cytometry	Human
Birebent B, Lorho R, Lechartier H, de Guibert S, Alizadeh M, Vu N, Beauplet A, Robillard N, Semana G Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression. Eur. J. Immunol., 2004-12-01;34(12):3485-96. 2004-12-01 [PMID: 15484187] (Flow Cytometry, Human)	Flow Cytometry	Human
Kieseier BC, #N*´)2ZP, Tani M, y§/ÔcØÞ, Mahad D, Oka N, Ho T, Woodroofe N, Griffin JW, Toyka KV, Ransohoff RM, Hartung HP Chemokines and chemokine receptors in inflammatory demyelinating neuropathies: a central role for IP-10. 2002-04-01;125(0):823-34. 2002-04-01 [PMID: 11912115] (IHC-P, Human)	IHC-P	Human
Lee B, Sharron M, Blanpain C, Doranz BJ, Vakili J, Setoh P, Berg E, Liu G, Guy HR, Durell SR, Parmentier M, Chang CN, Price K, Tsang M, Doms RW Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J. Biol. Chem., 1999-04-02;274(14):9617-26. 1999-04-02 [PMID: 10092648] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 17 Publications. Collapse Publications.

CCR5 Antibody (45523) [Unconjugated]

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Catalog# & Formulation	Size	Price
Carrier Free MAB181-SP

Gene Symbol	CCR5
Uniprot	P51681()