CCL3/MIP-1 alpha Antibody (769324) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL3, also known as macrophage inflammatory protein 1 alpha (MIP-1 alpha ) and LD78, is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta . Chemokines comprise a large family of small secreted proteins that are involved in immune and inflammatory responses. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells (1). Mature rat CCL3 shares 74%, 91%, and 88% amino acid sequence identity with human, mouse, and cotton rat CCL3, respectively (2). CCL3 is an approximately 8 kDa chemokine that forms complexes with sulfated proteoglycans (3, 4). In a reversible process, CCL3 associates into noncovalently-linked dimers which then form tetramers and high molecular weight polymers (5, 6). These complexes of CCL3 are protected from proteolytic digestion by insulin degrading enzyme (IDE) which can cleave the monomeric chemokine (6). CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5 (1). It is cleared from the extracellular space by internalization via the decoy chemokine receptor D6 (7). CCL3 promotes the chemoattraction, adhesion to activated vascular endothelium, and cellular activation of many hematopoietic cell types including activated T cells, NK cells, neutrophils, monocytes, immature dendritic cells, and eosinophils (1, 8-10). CCL3 is also known as stem cell inhibitor (SCI) and can inhibit the proliferation of hematopoietic progenitor cells (3). CCL3 bioactivity contributes to tumor metastasis and the inflammatory components of viral infection, rheumatoid arthritis, and hepatitis (11-14), although it also can suppress the replication of HIV (15). CCL3 additionally promotes hyperalgesia by sensitizing sensory neurons to TRPV1-mediated noxious stimulation (16).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 3 applications: Immunohistochemistry, In Vivo, Neutralization.

Showing Publications 1 - 3 of 3.

Publications using MAB66252	Applications	Species
Torres-Arévalo, Á;Nahuelpán, Y;Muñoz, K;Jara, C;Cappelli, C;Taracha-Wiśniewska, A;Quezada-Monrás, C;Martín, RS; A2BAR Antagonism Decreases the Glomerular Expression and Secretion of Chemoattractants for Monocytes and the Pro-Fibrotic M2 Macrophages Polarization during Diabetic Nephropathy International journal of molecular sciences 2023-06-29 [PMID: 37446007] (Immunohistochemistry, Neutralization, Rat)	Immunohistochemistry, Neutralization	Rat
Wenbo Wang, Baomei Qian, Chenhui Zhao, Mingyu Peng, Longfei Liu, Mengxiao Xie et al. Sublytic C5b-9 Induces CCL3/4 Production and Macrophage Accumulation in Thy-1N Rats via PKC-alpha /p65/IRF-8 Axis International Journal of Biological Sciences 5/1/2022 [PMID: 35637950]
Ochi-ishi , Ryutaro, Nagata , Kenichir, Inoue , Tomoyuki, Tozaki-Saitoh , Hidetosh, Tsuda , Makoto, Inoue , Kazuhide Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia. Mol Pain, 2014-08-15;10(0):53. 2014-08-15 [PMID: 25127716] (In Vivo, Rat)	In Vivo	Rat

Array MAB66252

• CCL3/MIP-1 alpha Antibodies
• CCL3/MIP-1 alpha ELISA Kits
• CCL3/MIP-1 alpha Lysate
• CCL3/MIP-1 alpha Proteins
• CCL3/MIP-1 alpha ELISAs
• CCL3/MIP-1 alpha Proteins and Enzymes