CCL3/CCL4 Antibody (93321) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The macrophage inflammatory proteins -1 alpha and -1 beta were originally co-purified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP‑1 alpha refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP‑1 alpha . Mature MIP-1 alpha and MIP‑1 beta in both human and mouse share approximately 70% homology at the amino acid level. The MIP‑1 proteins are members of the beta (C-C) subfamily of chemokines. Both MIP‑1 alpha and MIP-1 beta are monocyte chemoattractants in vitro. Additionally, the MIP‑1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP‑1 alpha and MIP‑1 beta preferentially attracting CD8⁺ and CD4⁺ T cells, respectively. MIP‑1 alpha has also been shown to attract B cells as well as eosinophils. MIP‑1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP‑1 alpha has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP‑1 alpha has been identified as CCR1 and CCR5.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 7 applications: Blocking, Co-Immunoprecipitation, ELISpot Development, ICC, IHC, IHC-Fr, Neutralization.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using MAB270	Applications	Species
Frank Cichocki, Ryan Bjordahl, Svetlana Gaidarova, Sajid Mahmood, Ramzey Abujarour, Hongbo Wang et al. iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy Science Translational Medicine 11/4/2020 [PMID: 33148626]
Jennifer A. Juno, Kathleen M. Wragg, Anne B. Kristensen, Wen Shi Lee, Kevin J. Selva, Renee M. van der Sluis et al. Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models Journal of Virology 6/1/2019 [PMID: 30867307]
W Sun, N Meednu, A Rosenberg, J Rangel-Mor, V Wang, J Glanzman, T Owen, X Zhou, H Zhang, BF Boyce, JH Anolik, L Xing B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation Nat Commun, 2018-12-03;9(1):5127. 2018-12-03 [PMID: 30510188] (Neutralization, Mouse)	Neutralization	Mouse
Lauren A Jordan, Malin C Erlandsson, Benjamin F Fenner, Ruth Davies, Ann K Harvey, Ernest H Choy et al. Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis Rheumatology (Oxford) 11/1/2018 [PMID: 30053130]
S Auclair, F Liu, Q Niu, W Hou, G Churchyard, C Morgan, N Frahm, S Nitayaphan, P Pitisuthit, S Rerks-Ngar, JT Kimata, L Soong, G Franchini, M Robb, J Kim, N Michael, H Hu Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection PLoS Pathog., 2018-02-23;14(2):e1006888. 2018-02-23 [PMID: 29474461] (Neutralization, Human)	Neutralization	Human
Rump L, Mattey D, Kehoe O, Middleton J An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine, 2017-09-01;97(0):133-140. 2017-09-01 [PMID: 28648867] (IHC-Fr, Human)	IHC-Fr	Human
HM Baldwin, MD Singh, V Codullo, V King, H Wilson, I McInnes, GJ Graham Elevated ACKR2 expression is a common feature of inflammatory arthropathies Rheumatology (Oxford), 2017-09-01;0(0):. 2017-09-01 [PMID: 28486662] (IHC, Human)	IHC	Human
Yi Li, Yuhuan Zheng, Tianshu Li, Qiang Wang, Jianfei Qian, Yong Lu et al. Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma Oncotarget 9/15/2015 [PMID: 26155942]
Kanegasaki S, Matsushima K, Shiraishi K, Nakagawa K, Tsuchiya T Macrophage inflammatory protein derivative ECI301 enhances the alarmin-associated abscopal benefits of tumor radiotherapy. Cancer Res, 2014-07-18;74(18):5070-8. 2014-07-18 [PMID: 25038226] (Co-Immunoprecipitation, Mouse)	Co-Immunoprecipitation	Mouse
Yin X, Johns S, Kim D, Mikulski Z, Salanga C, Handel T, Macal M, Zuniga E, Fuster M Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol, 2014-02-03;192(5):2133-42. 2014-02-03 [PMID: 24493818] (Blocking, Human)	Blocking	Human
Michelle L. Scalley-Kim, Bruce W. Hess, Ryan L. Kelly, Anne-Rachel F. Krostag, Kurt H. Lustig, John S. Marken et al. A Novel Highly Potent Therapeutic Antibody Neutralizes Multiple Human Chemokines and Mimics Viral Immune Modulation PLoS ONE 8/17/2012 [PMID: 22912856]
Snyder-Cappione JE, Tincati C, Eccles-James IG, Cappione AJ, Ndhlovu LC, Koth LL, Nixon DF A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-alpha and MIP1-beta, a lack of IL-17, and a Th1-bias in males. PLoS ONE, 2010-11-03;5(11):e15412. 2010-11-03 [PMID: 21082024] (ELISpot Development, Human)	ELISpot Development	Human
Franciszkiewicz K, Le Floc'h A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadiere C, Mami-Chouaib F Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res., 2009-07-28;69(15):6249-55. 2009-07-28 [PMID: 19638592] (ICC, Human)	ICC	Human
Fischer J, West J, Agochukwu N, Suire C, Hale-Donze H Induction of host chemotactic response by Encephalitozoon spp. Infect. Immun., 2006-12-18;75(4):1619-25. 2006-12-18 [PMID: 17178789] (Neutralization, Human)	Neutralization	Human
Show All 14 Publications. Collapse Publications.

Array MAB270

• CCL3/CCL4 Antibodies