Name: CCL2/JE/MCP-1 Antibody (24822) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB279
Price: 469 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, B/N
Clone	24822
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB279U

Alexa Fluor 405 FAB279V

Alexa Fluor 488 IC279G-025

Alexa Fluor 532 FAB279X

Alexa Fluor 594 FAB279T

Alexa Fluor 647 FAB279R

Alexa Fluor 700 FAB279N

Alexa Fluor 750 FAB279S

Allophycocyanin FAB279A

Biotin FAB279B

CoraFluor 1 FAB279CL1

DyLight 350 FAB279D

DyLight 405 FAB279E

DyLight 488 FAB279K

DyLight 550 FAB279L

DyLight 594 FAB279M

DyLight 650 FAB279W

DyLight 680 FAB279Y

DyLight 755 FAB279Z

FITC FAB279F

HRP FAB279H

Janelia Fluor 525 FAB279JF525

Janelia Fluor 549 FAB279I

Janelia Fluor 646 FAB279J

Janelia Fluor 669 FAB279JF669

PE FAB279P

PerCP FAB279C

mFluor Violet 450 SE FAB279MFV450

mFluor Violet 500 SE FAB279MFV500

mFluor Violet 610 SE FAB279MFV610

Catalog# & Formulation	Size	Price
Carrier Free MAB279-SP

Carrier Free IC279G-025

Carrier Free MAB279-500

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB279U
Alexa Fluor 405	FAB279V
Alexa Fluor 488	IC279G-025
Alexa Fluor 532	FAB279X
Alexa Fluor 594	FAB279T
Alexa Fluor 647	FAB279R
Alexa Fluor 700	FAB279N
Alexa Fluor 750	FAB279S
Allophycocyanin	FAB279A
Biotin	FAB279B
CoraFluor 1	FAB279CL1
DyLight 350	FAB279D
DyLight 405	FAB279E
DyLight 488	FAB279K
DyLight 550	FAB279L
DyLight 594	FAB279M
DyLight 650	FAB279W
DyLight 680	FAB279Y
DyLight 755	FAB279Z
FITC	FAB279F
HRP	FAB279H
Janelia Fluor 525	FAB279JF525
Janelia Fluor 549	FAB279I
Janelia Fluor 646	FAB279J
Janelia Fluor 669	FAB279JF669
PE	FAB279P
PerCP	FAB279C
mFluor Violet 450 SE	FAB279MFV450
mFluor Violet 500 SE	FAB279MFV500
mFluor Violet 610 SE	FAB279MFV610

CCL2/JE/MCP-1 Antibody (24822) [Unconjugated]

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CCL2/JE/MCP-1 Antibody (24822) [Unconjugated] Summary

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Publications for CCL2/JE/MCP-1 Antibody (MAB279)(28)

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Immunogen	E. coli-derived recombinant human CCL2/JE/MCP-1
Specificity	Detects human CCL2/JE/MCP-1 in Western blots. Does not cross-react with recombinant human (rh) CCL1, 3, 4, 5, 7, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, rmCCL1, 2, 3, 4, 5, 6, 7, 9/10MIP-1 gamma , 11, 12, 17, 19, 20, 22, 24, 25, or rrCCL20.
Source	N/A
Isotype	IgG1
Clonality	Monoclonal
Host	Mouse
Gene	CCL2
Purity Statement	Protein A or G purified from ascites
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB279	Applications	Species
Teizo Yoshimura, Chunning Li, Yuze Wang, Akihiro Matsukawa The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis Cellular & Molecular Immunology 2023-05-19 [PMID: 37208442]
R. C. Cornelison, J. X. Yuan, K. M. Tate, A. Petrosky, G. F. Beeghly, M. Bloomfield et al. A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment npj Precision Oncology 2022-07-29 [PMID: 35906273]
L Wang, J Lan, J Tang, N Luo MCP-1 targeting: Shutting off an engine for tumor development Oncology Letters, 2021-11-19;23(1):26. 11/19/2021 [PMID: 34868363]
Cynthia Hajal, Yoojin Shin, Leanne Li, Jean Carlos Serrano, Tyler Jacks, Roger D. Kamm The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain Science Advances 2021-06-25 [PMID: 34162553]
I Gomez, B Ward, C Souilhol, C Recarti, M Ariaans, J Johnston, A Burnett, M Mahmoud, LA Luong, L West, M Long, S Parry, R Woods, C Hulston, B Benedikter, C Niespolo, R Bazaz, S Francis, E Kiss-Toth, M van Zandvo, A Schober, P Hellewell, PC Evans, V Ridger Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium Nat Commun, 2020-01-10;11(1):214. 1/10/2020 [PMID: 31924781]
SW Lai, YS Liu, DY Lu, CF Tsai Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1 Nutrients, 2019-06-14;11(6):. 2019-06-14 [PMID: 31207928] (Neutralization, Human)	Neutralization	Human
Bianca Cioni, Ekaterina Nevedomskaya, Monique H. M. Melis, Johan van Burgsteden, Suzan Stelloo, Emma Hodel et al. Loss of androgen receptor signaling in prostate cancer‐associated fibroblasts (CAFs) promotes CCL2‐ and CXCL8‐mediated cancer cell migration Molecular Oncology 8/1/2018 [PMID: 29808619]
Mingjing Shen, Yongbing Chen, Lijun Xu, Rongying Zhu, Xiang Xue, Ying Tsai et al. Increased infiltration of macrophages to radioresistant lung cancer cells contributes to the development of the additional resistance of tumor cells to the cytotoxic effects of NK cells International Journal of Oncology 2018-05-04 [PMID: 29750425]
Lei Li, Yong-Dong Liu, Yu-Ting Zhan, Ying-Hui Zhu, Yan Li, Dan Xie et al. High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma Thoracic Cancer 2018-07-01 [PMID: 29722145]
Chang-Yun Liu, Zhen-Hua Zhao, Zhi-Ting Chen, Chun-Hui Che, Zhang-Yu Zou, Xiao-Min Wu et al. DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses Experimental and Therapeutic Medicine 2017-09-01 [PMID: 28962149]
M Yao, C Smart, Q Hu, N Cheng Continuous Delivery of Neutralizing Antibodies Elevate CCL2 Levels in Mice Bearing MCF10CA1d Breast Tumor Xenografts Transl Oncol, 2017-07-19;10(5):734-743. 2017-07-19 [PMID: 28734227] (Neutralization, Mouse)	Neutralization	Mouse
Vergani E, Di Guardo L, Dugo M et al. Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b. Oncotarget 1/26/2016 [PMID: 26684239]
Paul F Lindholm, Neela Sivapurapu, Borko Jovanovic, André Kajdacsy-Balla Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-kappa B Activity Journal of Clinical and Cellular Immunology 2015-08-29 [PMID: 26317041]
Maria Hårdstedt, Susanne Lindblom, Alex Karlsson-Parra, Bo Nilsson, Olle Korsgren Characterization of Innate Immunity in an Extended Whole Blood Model of Human Islet Allotransplantation Cell Transplantation 2016-03-01 [PMID: 26084381]
Mazumdar , Sohini, Arendt , Lisa M, Phillips , Sarah, Sedic , Maja, Kuperwasser , Charlott, Gill , Grace CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS ONE, 2015-03-20;10(3):e0121281. 2015-03-20 [PMID: 25793264] (Bioassay, Human)	Bioassay	Human
Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci, 2015-02-11;35(6):2452-64. 2015-02-11 [PMID: 25673840] (Neutralization, Rat)	Neutralization	Rat
Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J. Exp. Med., 2012-09-17;209(10):1813-23. 2012-09-17 [PMID: 22987802] (Neutralization, Human)	Neutralization	Human
Kazutoshi Fujita, Charles M. Ewing, Robert H. Getzenberg, J. Kellogg Parsons, William B. Isaacs, Christian P. Pavlovich Monocyte chemotactic protein-1 (MCP-1/CCL2) is associated with prostatic growth dysregulation and benign prostatic hyperplasia The Prostate 2010-04-01 [PMID: 19902472]
Dagouassat M, Suffee N, Hlawaty H, Haddad O, Charni F, Laguillier C, Vassy R, Martin L, Schischmanoff PO, Gattegno L, Oudar O, Sutton A, Charnaux N Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells. Int. J. Cancer, 2010-03-01;126(5):1095-108. 2010-03-01 [PMID: 19642141] (Neutralization, Human)	Neutralization	Human
Renaud SJ, Sullivan R, Graham CH Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells via differential activation of MAPK pathways. Placenta, 2009-02-08;30(4):313-9. 2009-02-08 [PMID: 19201463] (Neutralization, Human)	Neutralization	Human
Huang SJ, Chen CP, Schatz F, Rahman M, Abrahams VM, Lockwood CJ Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua. J. Pathol., 2008-02-01;214(3):328-36. 2008-02-01 [PMID: 18069648] (ELISA Development, IHC-Fr, Human)	ELISA Development, IHC-Fr	Human
Cheadle EJ, Riyad K, Subar D, Rothwell DG, Ashton G, Batha H, Sherlock DJ, Hawkins RE, Gilham DE Eotaxin-2 and colorectal cancer: a potential target for immune therapy. Clin. Cancer Res., 2007-10-01;13(19):5719-28. 2007-10-01 [PMID: 17908961] (ELISA Development, Human)	ELISA Development	Human
Fischer J, West J, Agochukwu N, Suire C, Hale-Donze H Induction of host chemotactic response by Encephalitozoon spp. Infect. Immun., 2006-12-18;75(4):1619-25. 2006-12-18 [PMID: 17178789] (Neutralization, Human)	Neutralization	Human
Abe Y, Fornage M, Yang CY, Bui-Thanh NA, Wise V, Chen HH, Rangaraj G, Ballantyne CM L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis, 2006-10-04;192(1):56-66. 2006-10-04 [PMID: 17022986] (Neutralization, Human)	Neutralization	Human
Haukeland JW, Damas JK, Konopski Z, Loberg EM, Haaland T, Goverud I, Torjesen PA, Birkeland K, Bjoro K, Aukrust P Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. J. Hepatol., 2006-03-20;44(6):1167-74. 2006-03-20 [PMID: 16618517] (IHC-P, Human)	IHC-P	Human
Penninckx F, Ectors N GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors. Exp. Cell Res., 2005-02-15;303(2):331-42. 2005-02-15 [PMID: 15652347] (ELISA Development, Human)	ELISA Development	Human
Kyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark-Lewis I, Rollins BJ, Bornstein P The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. Am. J. Pathol., 2004-12-01;165(6):2157-66. 2004-12-01 [PMID: 15579457] (ICC, Neutralization, Human)	ICC, Neutralization	Human
Megjugorac NJ, Young HA, Amrute SB, Olshalsky SL, Fitzgerald-Bocarsly P Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. J. Leukoc. Biol., 2004-01-23;75(3):504-14. 2004-01-23 [PMID: 14742635] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 28 Publications. Collapse Publications.