CASK Antibody - BSA Free

Calmodulin sensitive kinase (CASK/mLIN-2) is a ~112-kDa member of the membrane associated quanylate kinase (MAGUK) protein family with multiple protein binding domains. These include an N-terminal calmodulin kinase (CaMKII) domain and C-terminal PDZ, SH3-, and quanylate kinase domains. CASK possesses both tyrosine kinase and serine/threonine kinase activity. In addition, CASK can form a heterotrimeric complex with Mint (X11or mLIN-10) and Veli (mLIN-7) proteins which is predicted to participate in plasma membrane receptor localization. CASK is localized to neuronal synapses and also interacts with syndecan and neurexin. The guanylate kinase domain of CASK has been shown to interact with the T-box transcription factor, Tbr-1, as a coactivator to induce transcription of genes that contain T-elements.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC/IF, Simple Western, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-41181	Applications	Species
Becker M, Mastropasqua F, Reising JP et al. Presynaptic dysfunction in CASK-related neurodevelopmental disorders Transl Psychiatry 2020-09-14 [PMID: 32929080] (ICC/IF, Simple Western, WB, Human)	ICC/IF, Simple Western, WB	Human
Li D Genetic implications of individual intervention and neuronal dysfunction in neurodevelopmental disorders Thesis 2022-01-01 (ICC/IF, WB, Human)	ICC/IF, WB	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Martin Becker	Simple Western	Human	03/13/2017	View Summary Application Simple Western Sample Tested Differentiated neuron progenitor cells Species Human Comments Comments Protein lysates have been generated using detergent free lysis buffer (TrisHCl, NaCl, EDTA, EGTA) and 5 seconds of sonication.

Array NBP2-41181

• CASK Antibodies
• CASK Protein