CASK Products

Description

Calmodulin sensitive kinase (CASK/mLIN-2) is a ~112-kDa member of the membrane associated quanylate kinase (MAGUK) protein family with multiple protein binding domains. These include an N-terminal calmodulin kinase (CaMKII) domain and C-terminal PDZ, SH3-, and quanylate kinase domains. CASK possesses both tyrosine kinase and serine/threonine kinase activity. In addition, CASK can form a heterotrimeric complex with Mint (X11or mLIN-10) and Veli (mLIN-7) proteins which is predicted to participate in plasma membrane receptor localization. CASK is localized to neuronal synapses and also interacts with syndecan and neurexin. The guanylate kinase domain of CASK has been shown to interact with the T-box transcription factor, Tbr-1, as a coactivator to induce transcription of genes that contain T-elements.

Bioinformatics

Entrez	12361 Mouse 29647 Rat 8573 Human
Uniprot	NP_003679 Human O14936 Human Q62915 Rat
Product By Gene ID	8573
Alternate Names	calcium/calmodulin-dependent serine protein kinase (MAGUK family) calcium/calmodulin-dependent serine protein kinase membrane-associatedguanylate kinase Calcium/calmodulin-dependent serine protein kinase CAMGUK CMG EC 2.7.11 EC 2.7.11.1 FGS4CAGH39 FLJ22219 hCASK LIN2FLJ31914 MICPCH peripheral plasma membrane protein CASK Protein lin-2 homolog TNRC8 trinucleotide repeat containing 8

Research Areas for CASK

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Signal Transduction