Orthogonal Strategies: Western Blot: Calpain S1 Antibody [NBP1-90329] - Analysis in human cell lines A-549 and HEK293 using Calpain S1 antibody. Corresponding Calpain S1 RNA-seq data are presented for the same ...read more
Immunocytochemistry/ Immunofluorescence: Calpain S1 Antibody [NBP1-90329] - Staining of human cell line A-431 shows localization to nucleoplasm & cytosol. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Calpain S1 Antibody [NBP1-90329] - Staining of human stomach shows strong cytoplasmic positivity in glandular cells.
Western Blot: Calpain S1 Antibody [NBP1-90329] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.
This antibody was developed against Recombinant Protein corresponding to amino acids: THYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPG
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CAPNS1
Purity
Immunogen affinity purified
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Calpain S1 Antibody
Calcium-activated neutral proteinase small subunit
Calcium-dependent protease small subunit 1
calcium-dependent protease, small subunit
calpain 4, small subunit (30K)
Calpain regulatory subunit
calpain small subunit 1
calpain, small polypeptide
CALPAIN4
CANP
CANPS
CAPN4
CDPS
CSS1
epididymis secretory sperm binding protein
Background
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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