Recombinant Human BMP-7 Protein

This lyophilized preparation is stable for 12 months from date of receipt at -20 to -70 degrees C, preferably desiccated. Upon reconstitution, the preparation can be stored for 1 month at 2-8 degrees C under sterile conditions, and for 3 months at -20 degrees C to -70 degrees C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Stock solutions should be aliquoted and stored at < -20 degrees C. Further dilutions should be made in appropriate buffered solutions

Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP-1), is a widely expressed TGF-b superfamily member. Human BMP-7 is synthesized with a propeptide and a growth factor domain. It is secreted as a tetramer that consists of two cleaved propeptides and two disulfide-linked growth factor domains. Mature BMP-7 can also form disulfide-linked heterodimers with BMP-2 or BMP-4. Secreted BMP-7 is immobilized in the ECM through interactions with fibrillin. BMP-7 signals through complexes of type 2 receptors (Activin RIIA, Activin RIIB, and BMPR-II) and type 1 receptors (Activin RIA, BMPR-IA, and BMPR-IB). BMP-7 promotes new bone formation and nephron development, inhibits the branching of prostate epithelium, and antagonizes epithelial-mesenchymal transition (EMT). In disease, BMP-7 inhibits tumor growth and metastasis, ameliorates fibrotic damage in nephritis, and promotes neuroregeneration following brain ischemia.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Array NBP2-34933

• BMP-7 Antibodies
• BMP-7 ELISA Kits
• BMP-7 Lysate
• BMP-7 Proteins
• BMP-7 ELISAs
• BMP-7 Proteins and Enzymes