B7-2/CD86 Antibody (37301) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through Interferon-gamma . B7-1 and B7-2 are both members of the immunoglobulin superfamily. Human B7-2 is a 329 amino acid (aa) protein containing a putative 23 aa signal peptide, a 224 aa extracellular domain, a 21 aa transmembrane domain, and a 61 aa cytoplasmic domain. Human B7-2 and B7-1 share 26% amino acid identity. Human and mouse B7-2 share 50% amino acid identity. However, it has been observed that both human and mouse B7‑1 and B7‑2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 10 of 10.

Publications using FAB141P	Applications	Species
Bácsi, A;Ágics, B;Pázmándi, K;Kocsis, B;Sándor, V;Bertók, L;Bruckner, G;Sipka, S; Radiation-Detoxified Form of Endotoxin Effectively Activates Th1 Responses and Attenuates Ragweed-Induced Th2-Type Airway Inflammation in Mice International journal of molecular sciences 2024-01-27 [PMID: 38338861] (Flow Cytometry, Human)	Flow Cytometry	Human
L Hyväri, M Ojansivu, M Juntunen, K Kartasalo, S Miettinen, S Vanhatupa Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages Stem Cells Int, 2018-09-12;2018(0):2190657. 2018-09-12 [PMID: 30275837] (Flow Cytometry, Human)	Flow Cytometry	Human
M Ojansivu, A Mishra, S Vanhatupa, M Juntunen, A Larionova, J Massera, S Miettinen The effect of S53P4-based borosilicate glasses and glass dissolution products on the osteogenic commitment of human adipose stem cells PLoS ONE, 2018-08-28;13(8):e0202740. 2018-08-28 [PMID: 30153295] (Flow Cytometry, Human)	Flow Cytometry	Human
Z Agod, K Pazmandi, D Bencze, G Vereb, T Biro, A Szabo, E Rajnavolgy, A Bacsi, P Engel, A Lanyi Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic CellsStabilization of Interferon Regulatory Factor 8 Front Immunol, 2018-01-26;9(0):62. 2018-01-26 [PMID: 29434592] (Flow Cytometry, Human)	Flow Cytometry	Human
Z Agod, T Fekete, MM Budai, A Varga, A Szabo, H Moon, I Boldogh, T Biro, A Lanyi, A Bacsi, K Pazmandi Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells Redox Biol, 2017-07-29;13(0):633-645. 2017-07-29 [PMID: 28818792] (Flow Cytometry, Human)	Flow Cytometry	Human
KP Bene, DW Kavanaugh, C Leclaire, AP Gunning, DA MacKenzie, A Wittmann, ID Young, N Kawasaki, E Rajnavolgy, N Juge Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors Front Microbiol, 2017-03-07;8(0):321. 2017-03-07 [PMID: 28326063] (Flow Cytometry, Human)	Flow Cytometry	Human
Fekete T, Pazmandi K, Szabo A, Bacsi A, Koncz G, Rajnavolgyi E The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of rapamycin. J Leukoc Biol, 2014-07-07;96(4):579-89. 2014-07-07 [PMID: 25001862] (Flow Cytometry, Human)	Flow Cytometry	Human
Chiang CL, Ledermann JA, Aitkens E, Benjamin E, Katz DR, Chain BM Oxidation of ovarian epithelial cancer cells by hypochlorous acid enhances immunogenicity and stimulates T cells that recognize autologous primary tumor. Clin. Cancer Res., 2008-08-01;14(15):4898-907. 2008-08-01 [PMID: 18676764] (Flow Cytometry, Human)	Flow Cytometry	Human
Lotfi R, Lotze MT Eosinophils induce DC maturation, regulating immunity. J. Leukoc. Biol., 2007-11-08;83(3):456-60. 2007-11-08 [PMID: 17991762] (Flow Cytometry, Human)	Flow Cytometry	Human
Kaur K, Chowdhury S, Greenspan NS, Schreiber JR Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates. Blood, 2007-07-18;110(8):2948-54. 2007-07-18 [PMID: 17634409] (Flow Cytometry, Human)	Flow Cytometry	Human

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	Flow	Human	01/21/2015	View Summary Application Flow Cytometry Sample Tested See PMID: 22517920 Species Human

Array FAB141P

• B7-2/CD86 Antibodies
• B7-2/CD86 Antibody Pairs
• B7-2/CD86 ELISA Kits
• B7-2/CD86 Proteins
• B7-2/CD86 Proteins and Enzymes
• B7-2/CD86 ELISA