B7-2/CD86 Antibody (37301) [Fluorescein]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon gamma . B7-1 and B7-2 are both members of the immunoglobulin superfamily. Human B7-2 is a 329 amino acid (aa) protein containing a putative 23 aa signal peptide, a 224 aa extracellular domain, a 21 aa transmembrane domain, and a 61 aa cytoplasmic domain. Human B7-2 and B7-1 share 26% amino acid identity. Human and mouse B7-2 share 50% amino acid identity. However, it has been observed that both human and mouse B7‑1 and B7‑2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 2 of 2.

Publications using FAB141F	Applications	Species
Mona S Abdellateif, Sabry M Shaarawy, Eman Z Kandeel, Ahmed H El‑Habashy, Mohamed L Salem, Motawa E El‑Houseini A novel potential effective strategy for enhancing the antitumor immune response in breast cancer patients using a viable cancer cell‑dendritic cell‑based vaccine Oncology Letters 5/4/2018 [PMID: 29928442]
Kraetzel K, Stoelcker B, Eissner G, Multhoff G, Pfeifer M, Holler E, Schulz C NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells. Eur. Respir. J., 2008-04-16;32(3):563-70. 2008-04-16 [PMID: 18417514] (Flow Cytometry, Human)	Flow Cytometry	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Flow	Human	03/01/2019	View Summary Application Flow Cytometry Sample Tested Human PBMC Species Human Lot LCS0419011 Comments Comments Human PBMCs were stained with anti-human CD86 FITC.

Array FAB141F

• B7-2/CD86 Antibodies
• B7-2/CD86 Antibody Pairs
• B7-2/CD86 ELISA Kits
• B7-2/CD86 Proteins
• B7-2/CD86 Proteins and Enzymes
• B7-2/CD86 ELISA