ATP7b Antibody

ATP7b (copper-transporting P-type adenosine triphosphatase) is also called copper-transporting ATPase 2 or Wilson disease-associated protein and is involved in copper export out of the cells, such as the efflux of hepatic copper into the bile. ATP7b is a monomeric protein that interacts with COMMD1/MURR1, DCTN4 (in copper-dependent manner) and ATOX1. Predominantly localized in the trans-Golgi network (TGN), ATP7b is most abundantly expressed in liver, kidney and the brain tissues (isoform 2 is expressed in cytoplasm of brain cells but not in liver). Isoform 1 is proteolytically cleaved at N-terminus to produce the WND/140 kD form which is found in mitochondrions of hepatocytes as well as other tissue/cell types. Defects in ATP7B have been linked to Wilson disease (WD), an autosomal recessive disorder of copper metabolism, wherein, copper cannot be incorporated into hepatic ceruloplasmin and cannot be excreted from the liver into the bile.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-361	Applications	Species
Nguyen P, Chakrabarti J, Li Y et al Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Frontiers in Oncology 2019-10-01 [PMID: 31632904] (WB, Human)	WB	Human
Yoshizawa K, Nozaki S, Kitahara H et al. Copper efflux transporter (ATP7B) contributes to the acquisition of cisplatin-resistance in human oral squamous cell lines. Oncol Rep. 2007-10-01 [PMID: 17786364] (WB, Human)	WB	Human
Guo, Y et al. NH2-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells. Am J Physiol Gastrointest Liver Physiol;289(5):G904-16. 2005-11-01 [PMID: 15994426] (WB, Rat, Human)	WB	Rat, Human

Array NB100-361

• ATP7b Antibodies
• ATP7b ELISA Kits
• ATP7b Lysate
• ATP7b Proteins