ATP6V0C Antibody

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 6 of 6.

Publications using NBP1-59654	Applications	Species
Delong Meng, Qianmei Yang, Mi-Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Chase H. Melick, Tshering D. Lama-Sherpa, Huanyu Wang, Mariela Huerta-Rosario, Greg Urquhart, Lauren G. Zacharias, Cheryl Lewis, Ralph J. DeBerardinis, Jenna L. Jewell SNAT7 regulates mTORC1 via macropinocytosis Proceedings of the National Academy of Sciences of the United States of America 2022-05-13 [PMID: 35561222]
Ma T, Tian X, Zhang B et al. Low-dose metformin targets the lysosomal AMPK pathway through PEN2 Nature 2022-03-01 [PMID: 35197629] (WB, Mouse)	WB	Mouse
Weber RA, Yen FS, Nicholson SPV et al. Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation Mol. Cell 2020-01-15 [PMID: 31983508] (WB, Human)	WB	Human
Li M, Zhang CS, Zong Y et al. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK Virchows Arch. 2019-06-10 [PMID: 31204282]
Merk H, Messer P, Ardelt MA et al. Inhibition of the V-ATPase by Archazolid A - a new strategy to inhibit EMT. Mol. Cancer Ther. 2017-08-03 [PMID: 28775146] (WB)	WB
Zhang CS, Li M, Ma T et al. Metformin Activates AMPK through the Lysosomal Pathway. Cell Metab 2016-10-11 [PMID: 27732831]

Array NBP1-59654

• ATP6V0C Antibodies
• ATP6V0C Lysate
• ATP6V0C Protein