RPL7A Antibody

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-2277	Applications	Species
McCoy M, Poliquin-Duchesneau D, Corbin F. Molecular dynamics of FMRP and other RNA-binding proteins in MEG-01 differentiation: the role of mRNP complexes in non-neuronal development. Biochem Cell Biol 2016-12-01 [PMID: 27860518]
El Fatimy R, Davidovic L, Tremblay S et al. Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules. PLoS Genet. 2016-07-01 [PMID: 27462983] (WB, Mouse)	WB	Mouse
Lauziere V, Lessard M, Meunier AJ et al. Unusual subcellular confinement of the fragile X mental retardation protein (FMRP) in human platelets: Complete polyribosome dissociation. Biochimie. 2011-12-21 [PMID: 22210492]
Frolova EI, Gorchakov R, Pereboeva L et al. Functional Sindbis virus replicative complexes are formed at the plasma membrane. J Virol 2010-11-01 [PMID: 20826696]

Array NB100-2277

• RPL7A Antibodies
• RPL7A Lysate
• RPL7A Protein