Recombinant Mouse IL-9 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-9 (IL-9), also known as P40 and MEA (mast cell growth-enhancing activity), is a 30-40 kDa glycosylated member of a cytokine family that includes Interleukins-2, -4, -7, -15, and -21. These proteins utilize heteromeric receptors containing the Common gamma chain ( gamma c) in addition to ligand-specific subunits. IL-9 interacts selectively with IL-9 R which then associates with gamma c to form the functional receptor complex. IL-9 contributes to allergic inflammation, autoimmunity-induced inflammation, parasite clearance from the GI tract, and Treg-mediated immune suppression (1, 2). It enhances the expansion and recruitment of mast cells and eosinophils as well as the production of IgE and Th2 cytokines (3‑6). It is required for anaphylactic responses to ingested allergens but not to systemic allergens (7). IL-9 plays multiple roles in the development and function of subsets within the CD4⁺ T cell lineage (8). It is expressed by activated Th9, Th17, Treg, and Th2 cells (3, 9‑12). IL-9 acts as an autocrine growth and activation factor for Th17, Treg, and mast cells (3, 11, 13). It also can inhibit immune responses by enhancing the suppressive properties of Treg and by recruiting immune-suppressive mast cells to sites of inflammation (11, 12). Mature mouse IL-9 shares 57% and 74% amino acid sequence identity with human and rat IL-9, respectively (14).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: Bioassay, In Vivo, In vivo assay.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using 409-ML	Applications	Species
Lim, YJ;Park, SA;Wang, D;Jin, W;Ku, WL;Zhang, D;Xu, J;Patiño, LC;Liu, N;Chen, W;Kazmi, R;Zhao, K;Zhang, YE;Sun, L;Chen, W; MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells Cell reports 2024-07-30 [PMID: 39083380] (Bioassay, Mouse)	Bioassay	Mouse
Cao, Z;Wang, J;Liu, X;Liu, Y;Li, F;Liu, M;Chiu, S;Jin, X; Helminth alleviates COVID-19-related cytokine storm in an IL-9-dependent way mBio 2024-05-10 [PMID: 38727220] (In vivo assay, Mouse)	In vivo assay	Mouse
KM Deng, XS Yang, Q Luo, YX She, QY Yu, XX Tang Deleterious Role of Th9 Cells in Pulmonary Fibrosis Cells, 2021-11-17;10(11):. 2021-11-17 [PMID: 34831433] (Bioassay, Mouse)	Bioassay	Mouse
T Yashiro, H Ogata, SF Zaidi, J Lee, S Hayashi, T Yamamoto, M Kadowaki Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice Cells, 2021-06-23;10(7):. 2021-06-23 [PMID: 34201851] (Bioassay, Mouse)	Bioassay	Mouse
X Liu, F Zhou, W Wang, G Chen, Q Zhang, R Lv, Z Zhao, X Li, Q Yu, JM Meves, H Hua, X Li, X Wang, H Sun, D Gao IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis Journal of Neuroinflammation, 2021-05-11;18(1):108. 2021-05-11 [PMID: 33971906] (Bioassay, Mouse)	Bioassay	Mouse
RR Almeida, RS Vieira, A Castoldi, FF Terra, ACL Melo, MCC Canesso, L Lemos, M Cipelli, N Rana, MI Hiyane, EL Pearce, FDS Martins, AMC Faria, NOS Câmara Host dysbiosis negatively impacts IL-9-producing T-cell differentiation and antitumour immunity Br. J. Cancer, 2020-06-05;0(0):. 2020-06-05 [PMID: 32499569] (Bioassay, Mouse)	Bioassay	Mouse
N Liu, Y Jiang, J Chen, H Nan, Y Zhao, X Chu, A Wang, D Wang, T Qin, S Gao, Q Yi, Y Yue, S Wang IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells Cell. Mol. Immunol., 2018-10-01;0(0):. 2018-10-01 [PMID: 30275536] (Mouse)		Mouse
Turner , Jan-Eric, Morrison , Peter J, Wilhelm , Christop, Wilson , Mark, Ahlfors , Helena, Renauld , Jean-Chr, Panzer , Ulf, Helmby , Helena, Stockinger , Brigitta IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med, 2013-11-18;210(13):2951-65. 2013-11-18 [PMID: 24249111] (Bioassay, Mouse)	Bioassay	Mouse
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat. Med., 2012-07-08;1248(0):18. 2012-07-08 [PMID: 22772464] (In Vivo, Mouse)	In Vivo	Mouse
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)	Bioassay	Mouse
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)	In Vivo	Mouse
Vang KB, Yang J, Mahmud SA, Burchill MA, Vegoe AL, Farrar MA IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J. Immunol., 2008-09-01;181(5):3285-90. 2008-09-01 [PMID: 18714000] (Bioassay, Mouse)	Bioassay	Mouse
Reader JR, Hyde DM, Schelegle ES, Aldrich MC, Stoddard AM, McLane MP, Levitt RC, Tepper JS Interleukin-9 induces mucous cell metaplasia independent of inflammation. Am. J. Respir. Cell Mol. Biol., 2003-06-01;28(6):664-72. 2003-06-01 [PMID: 12760964] (In Vivo, Mouse)	In Vivo	Mouse
Show All 13 Publications. Collapse Publications.

Array 409-ML

• IL-9 Antibodies
• IL-9 ELISA Kit
• IL-9 Lysate
• IL-9 Proteins
• IL-9 ELISAs
• IL-9 Proteins and Enzymes