AIF1 Antibody was detected in immersion fixed paraffin-embedded sections of human Brain Cortex using Mouse Anti-Human AIF1, Monoclonal Antibody (Catalog # MAB7308) at 5ug/mL at 37 ° Celsius for 8 minutes. Before ...read more
AIF-1/Iba1 was detected in immersion fixed paraffin-embedded sections of human spleen using Mouse Anti-Human AIF-1/Iba1 Monoclonal Antibody (Catalog # MAB7308) at 0.5 µg/mL for 1 hour at room temperature followed by ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL. For liquid material, refer to CoA for concentration.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for AIF-1/Iba1 Antibody (603102) [Unconjugated]
AIF1
AIF-1
allograft inflammatory factor 1
G1
IBA1
IbaI
interferon gamma responsive transcript
Ionized calcium-binding adapter molecule 1
IRT1
IRT-1
Protein G1
Background
Allograft-inflammatory factor 1 (AIF-1),
also known as daintain and Iba1, is a 17 kDa cytoplasmic protein that contains
two calcium-binding EF hand motifs (aa 45-80 and aa 81-115). AIF-1 is expressed
in activated macrophages and is important for the proinflammatory response to
ischemia, tissue injury, and atherosclerosis. It is also expressed in vascular
smooth muscle and endothelial cells in these areas where it promotes vascular
remodeling and new vessel formation. AIF-1 is upregulated in allografted tissue
during transplant rejection. It also promotes the proliferation of breast
cancer cells and in vivo
tumorigenesis. The 147 amino acid (aa) isoform 3 of human AIF-1 shares 89% aa
sequence identity with mouse and rat AIF-1. Isoform 1 of human AIF-1 lacks the
N-terminal 54 aa of isoform 3. Isoform 2 lacks aa 1-54 as well as aa 121-147
but also has a 66 aa insertion at position 65.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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