Adenosine Deaminase/ADA Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Adenosine Deaminase (ADA, adenosine aminohydrolase) is one of the key enzymes of purine nucleotide catabolism. It catalyses the hydrolytic deamination of adenosine and deoxy‑adenosine to inosine and deoxyinosine (1, 2). ADA is expressed in virtually all tissues and is expressed at high levels in T-lymphocytes. Adenosine Deaminase deficiency can cause a form of SCID (severe combined immunodeficiency) and lymphopenia in both B- and T-cell lineages (3, 4). ADA can be used as a sensitive diagnostic marker for tuberculous pleuritis (5). Although it is primarily a cytosolic enzyme, ADA is known to be a positive regulator of T-cell co‑activation due to its binding to CD26 at the cell surface. The interaction of ADA with CD26 regulates lymphocyte-epithelial cell adhesion (6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using AF7048	Applications	Species
FA Moretti, G Giardino, TCH Attenborou, AS Gkazi, BK Margetts, G la Marca, L Fairbanks, T Crompton, HB Gaspar Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy Scientific Reports, 2021-12-01;11(1):23221. 2021-12-01 [PMID: 34853379] (Western Blot, Mouse)	Western Blot	Mouse

Array AF7048

• Adenosine Deaminase/ADA Antibodies
• Adenosine Deaminase/ADA ELISA Kit
• Adenosine Deaminase/ADA Kit
• Adenosine Deaminase/ADA Proteins
• Adenosine Deaminase/ADA Proteins and Enzyme