ACAT1 Antibody

Sterol O-acyltransferase 1 (SOAT1), also known as ACAT1, catalyzes the formation of intracellular cholesterol esters in various tissues, such as adult human liver, adrenal glands, macrophages, and kidneys. Specifically, ACAT-1 catalyzes the reversible reaction forming acetoacetyl-CoA from two molecules of acetyl-CoA. Additionaly, the ACAT 1 protein may have a role in lipoprotein assembly and dietary cholesterol absorption, and may also act as a ligase.

Mutations in this gene have been associated with 3-ketothiolase deficiency, an inborn defect of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-89285	Applications	Species
Janikiewicz J, Dobosz AM, Majzner K et al. Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced lipotoxicity by the formation of small lipid droplets in pancreatic ?-cells Biochimica et biophysica acta. Molecular basis of disease 2023-04-11 [PMID: 37054998] Details: Tested with INS-1E cells
Mulye M, Zapata B, Gilk SD et al. Altering lipid droplet homeostasis affects Coxiella burnetii intracellular growth PLoS One. 2018-01-31 [PMID: 29390006] (WB, Mouse)	WB	Mouse
Saadane A, Mast N, Dao T et al. Retinal hypercholesterolemia triggers cholesterol accumulation and esterification in photoreceptor cells. J. Biol. Chem. 2016-08-11 [PMID: 27514747] (WB, IF/IHC, Mouse)	WB, IF/IHC	Mouse
Sanchez-Alvarez R, Martinez-Outschoorn UE, Lin Z et al. Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: Implications for breast cancer prevention. Cell Cycle 2013-01-15 [PMID: 23257780]
Stadler C, Hjelmare M, Neumann B et al. Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. J Proteomics 2012-04-03 [PMID: 22361696]

Array NBP1-89285

• ACAT1 Antibodies
• ACAT1 Proteins
• ACAT1 Proteins and Enzyme