5-HT2C Antibody (JA31-31)

Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder and anxiety. It is also believed to be influential on sexuality and appetite. 5-HT is generally thought not to be released from synaptic terminal buttons in the manner of classical neurotransmission but from serotonergic varacosities into the extra neuronal space. From here it is free to diffuse over a relatively large region of space (>20um) and activate 5-HT receptors located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons. Serotonergic action is terminated primarily via uptake of 5-HT from the synapse. This is through the specific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynaptic neuron. The pharmacology of 5-HT is extremely complex, with its actions being mediated by a large and diverse range of 5-HT receptors.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: IHC-FrFl.

Showing Publication 1 - 1 of 1.

Publication using NBP2-67100	Applications	Species
Štepánková K, Chudí?ková M, Šimková Z et al. Oral administration of 4-methylumbelliferone reduces glial scar and promotes anatomical plasticity bioRxiv 2023-02-04 (IHC-FrFl, Rat)	IHC-FrFl	Rat

Array NBP2-67100

• 5-HT2C Antibodies
• 5-HT2C Lysate
• 5-HT2C Protein