DIO2 Antibody

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Sheep.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 8 of 8.

Publications using NBP1-00178	Applications	Species
Devalraju Kp, Tripathi D, Neela Vsk Et Al. Reduced thyroxine production in young household contacts of tuberculosis patients increases active tuberculosis disease risk JCI insight 2021-07-08 [PMID: 34236051] (WB)	WB
Myers DA, Singleton K, Hyatt K et al. Long term hypoxia during gestation alters perirenal adipose tissue gene expression in the lamb Adipocyte 2020-12-01 [PMID: 32403966] (WB, Sheep)	WB	Sheep
Zuo Z, Liu Z, Gao T et al. Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice Sci. Total Environ. 2019-06-10 [PMID: 30852208] (WB, Mouse)	WB	Mouse
AC Guénantin, N Briand, E Capel, F Dumont, R Morichon, C Provost, F Stillitano, D Jeziorowsk, JP Siffroi, RJ Hajjar, B Fève, JS Hulot, P Collas, J Capeau, C Vigouroux Functional Human Beige Adipocytes from Induced Pluripotent Stem Cells Diabetes, 2017-03-07;0(0):. 2017-03-07 [PMID: 28270520]
Kishida T, Ejima A, Yamamoto K et al. Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes. Stem Cell Reports 2015-09-09 [PMID: 26365511] (ICC/IF, Human, Mouse)	ICC/IF	Human, Mouse
Vose LR, Vinukonda G, Jo S et al. Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage. J Neurosci. 2013-10-30 [PMID: 24174657] (ICC/IF, IF/IHC, Human)	ICC/IF, IF/IHC	Human
Langford D, Baron D, Joy J et al. Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation Psychoneuroendocrinology 2011-06-01 [PMID: 21115295] (WB, Human)	WB	Human
Gumieniak O, Perlstein TS, Williams JS et al. Ala92 Type 2 Deiodinase Allele Increases Risk for the Development of Hypertension. Hypertension 2007-01-15 [PMID: 17224473]

Array NBP1-00178

• DIO2 Antibodies
• DIO2 ELISA Kits
• DIO2 Proteins