15-PGDH/HPGD Antibody

15-PGDH (15-hydroxyprostaglandin dehydrogenase, NAD+ or HPGD) belongs to short-chain dehydrogenases/reductases (SDR) family and is a key enzyme responsible for biological inactivation of prostaglandins as well as related eicosanoids. 15-PGDH has a potential to catalyze NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4, and it brings about prostaglandin inactivation for regulating biological processes which are controlled by prostaglandin levels. It is down-regulated by cortisol, dexamethasone and betamethasone, and TGFB1. 15-PGDH is considered as a tumor suppressor and its decreased expression is observed in cancers subjects with colorectal, breast, prostate, lung, thyroid, gastric and other cancers. Furthermore, defects in 15-PGDH gene have been linked to diseases including hypertrophic osteoarthropathy, primary, autosomal recessive, type 1 (PHOAR1), cranioosteoarthropathy (COA), isolated congenital nail clubbing (ICNC).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 10 of 29. Show All 29 Publications. Collapse Publications.

Publications using NB200-179	Applications	Species
Ghatak S, Mehrabi SF, Mehdawi LM et al. Identification of a Novel Five-Gene Signature as a Prognostic and Diagnostic Biomarker in Colorectal Cancers International journal of molecular sciences 2022-01-12 [PMID: 35054980] (IHC-P, Human)	IHC-P	Human
Volpato M, Cummings M, Shaaban A et al. Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ER alpha-positive breast cancer Exploration of Targeted Anti-tumor Therapy 2020-10-19 [PMID: 33210098] (Human)		Human
Corwin C, Nikolopoulou A, Pan AL et al. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. J Neuroinflammation 2018-09-20 [PMID: 30236122] (ICC/IF, Rat)	ICC/IF	Rat
Yao L, Chen W, Song K et al. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury. PLoS ONE. 2017-04-19 [PMID: 28423012] (IHC-P, Mouse)	IHC-P	Mouse
Mehdawi LM, Satapathy SR, Gustafsson A et al. A potential anti-tumor effect of leukotriene C4 through the induction of 15-hydroxyprostaglandin dehydrogenase expression in colon cancer cells. Oncotarget. 2017-05-23 [PMID: 28402256] (IF/IHC, ICC/IF, Human)	IF/IHC, ICC/IF	Human
Loo T M, Kamachi F et al. Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity. Cancer Discov 2017-01-05 [PMID: 28202625] (WB, Mouse)	WB	Mouse
Prima V, Kaliberova LN, Kaliberov S et al. COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells Proc. Natl. Acad. Sci. U.S.A 2017-01-17 [PMID: 28096371] (WB, Mouse)	WB	Mouse
Mehdawi LM, Prasad CP, Ehrnstrom R et al. Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells. Mol Oncol. 2016-08-01 [PMID: 27522468] (WB, IF/IHC)	WB, IF/IHC
Miyagishi H, Kosuge Y, Takano A et al. Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis. Cell. Mol. Neurobiol. 2016-05-02 [PMID: 27140190] (IHC-Fr, WB, Mouse)	IHC-Fr, WB	Mouse
Hsiao HM, Thatcher TH, Colas RA et al. Resolvin D1 Reduces Emphysema and Chronic Inflammation. Am J Pathol 2015-12-01 [PMID: 26468975]
Ryu YM, Myung SJ, Park YS et al. Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by Helicobacter pylori in Human Gastric Carcinogenesis Cancer Prev Res (Phila) 2013-03-12 [PMID: 23430757] (WB, Human)	WB	Human
Kang PS, Kim JH, Moon OI et al. Prognostic implication of 15-hydroxyprostaglandin dehydrogenase down-regulation in patients with colorectal cancer J Korean Soc Coloproctol 2012-10-01 [PMID: 23185705] (IF/IHC, Human)	IF/IHC	Human
Subbaramaiah K, Howe LR, Zhou XK et al. Pioglitazone, a PPARgamma Agonist, Suppresses CYP19 Transcription: Evidence for Involvement of 15-Hydroxyprostaglandin Dehydrogenase and BRCA1 Cancer Prev Res 2012-10-01 [PMID: 22787115] (WB, Human)	WB	Human
Osman J CysLT1 receptor signaling and the tumor microenvironment in colon cancer models Thesis 2020-01-01
de Hair MJ, Leclerc P, Newsum EC et al. Expression of Prostaglandin E2 Enzymes in the Synovium of Arthralgia Patients at Risk of Developing Rheumatoid Arthritis and in Early Arthritis Patients. PLoS ONE. 2015-08-03 [PMID: 26225917] (IF/IHC, Human)	IF/IHC	Human
Gheorghe KR, Sadique S, Leclerc P et al. Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue Arthritis Res Ther 2012-05-22 [PMID: 22616846] (ICC/IF, IHC-Fr, Human)	ICC/IF, IHC-Fr	Human
Chung HW, Lim JH, Kim MY, Shin SJ, Chung S, Choi BS, Kim HW, Kim YS, Park CW, Chang YS. High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPAR?-FoxO3a-PGC-1? pathway. Nephrol Dial Transplant. 2011-11-09 [PMID: 22076434] (WB, Rat)	WB	Rat
Judson BL, Miyaki A, Kekatpure VD et al. UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression Cancer Prev Res (Phila) 2010-09-01 [PMID: 20643784] (WB, Human)	WB	Human
Miyaki A, Yang P, Tai H-H et al. Bile acids inhibit NAD+-dependent 15-hydroxyprostaglin dehydrogenase transcription in colonocytes. Am J Physiol Gastrointest Liver Physiol;297(3):G559-566. 2009-01-01 [PMID: 19608733]
Thirumangalakudi L, Rao HV, Grammas P. Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis. Neurosci Lett 2009-03-13 [PMID: 19383433] (WB, Rat)	WB	Rat
Hughes D, Otani T, Yang P et al. NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non-Small Cell Lung Cancer. Cancer Prev Res (Phila Pa) 2008-09-01 [PMID: 19138967]
Backlund MG, Mann JR, Holla VR et al. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res 68(22):9331-7. 2008-11-15 [PMID: 19010907]
Michelet JF, Colombe L, Gautier B et al. Expression of NAD+ dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle. Exp Dermatol 2008-10-01 [PMID: 18328086] (WB, Human)	WB	Human
Mann, JR et al. Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression. Cancer Res 66(13):6649-56. 2006-07-01 [PMID: 16818638]
Yan, M et al. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A 101(50):17468-73. 2004-12-14 [PMID: 15574495] (WB, IF/IHC, Human)	WB, IF/IHC	Human
Backlund, MG et al. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J Biol Chem 280(5):3217-23. 2005-02-04 [PMID: 15542609]
Ding, Y et al. NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer. Carcinogenesis 26(1):65-72. 2005-01-01 [PMID: 15358636]
Tong, M, Tai, H-H. Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells. Endocrinology 145(5):2141-7. 2004-05-01 [PMID: 14749354]
Tai, CL et al. Monoclonal antibodies that inhibit the enzyme activity of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Biochem J 267(1):75-8. 1990-04-01 [PMID: 1691637] (Human)		Human
Show All 29 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IF	Human	06/07/2018	View Summary Application Immunofluorescence Sample Tested Fetal membranes Species Human Lot D-1
Enlarge	5 reviewed by: James Xiao	WB	Human	05/28/2014	View Summary Application Western Blot Sample Tested Human ling tissue lysates Species Human Lot C-3
Enlarge	4 reviewed by: Marina Korotkova	ICC	Human	08/17/2012	View Summary Application Immunocytochemistry Sample Tested synovial tissue from patient with rheumatoid arthritis Species Human

Array NB200-179

• 15-PGDH/HPGD Antibodies
• 15-PGDH/HPGD Antibody Pair
• 15-PGDH/HPGD ELISA Kit
• 15-PGDH/HPGD Lysate
• 15-PGDH/HPGD Proteins
• 15-PGDH/HPGD Proteins and Enzyme