Orthogonal Strategies: Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Analysis in human seminal vesicle and pancreas tissues. Corresponding Prostaglandin E Synthase RNA-seq data ...read more
Immunocytochemistry/ Immunofluorescence: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human cell line SiHa shows localization to endoplasmic reticulum. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human urinary bladder shows moderate cytoplasmic positivity in urothelial cells.
Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human placenta shows strong cytoplasmic positivity in decidual cells.
Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human seminal vesicle shows strong membranous and cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human testis shows weak to moderate membranous and cytoplasmic positivity in cells in seminiferous ducts.
Mouse reactivity reported in scientific literature (PMID: 27102561).
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Prostaglandin E Synthase Antibody
EC 5.3.99.3
MGC10317
MGST1L1
MGST1-L1
MGST1L1MGST1-like 1
MGST1-L1mPGES-1
MGST-IV
Microsomal glutathione S-transferase 1-like 1
Microsomal prostaglandin E synthase 1
MPGES
MPGES1
MPGES-1
p53-induced apoptosis protein 12
p53-induced gene 12 protein
PGES
PGESmicrosomal prostaglandin E synthase-1
PIG12
PIG12glutathione S-transferase 1-like 1
PP102
PP1294
Prostaglandin E Synthase
PTGES
TP53I12
tumor protein p53 inducible protein 12
Background
Prostaglandin E Synthase is encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq]
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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