YAP1 Antibody (867711) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

YAP1 (Yes-associated protein 1), also called YAP65 or Yorkie Homolog, is a widely expressed 65 kDa cytoplasmic and nuclear transcriptional regulator protein in the Hippo pathway that regulates organ size. The 504 amino acid (aa) human YAP1 contains two WW (tryptophan-containing protein binding) domains (aa 171-263), a transactivation domain (aa 219-504) and 19 sites that may be phosphorylated by kinases such as LATS1 and 2, MAPK8 and 9, CK1, or ABL1. Isoforms of 488, 454 and 326 aa lack aa 328-343, 230-267 (plus a 3 aa substitution for aa 329-343), or 1-178, respectively. YAP1 binds the Yes tyrosine kinase SH3 domain and many other proteins, notably ErbB4. YAP1 expression is increased in some liver and prostate cancers. Within aa 347-504, human YAP1 shares 94% and 93% aa sequence identity with mouse and rat YAP1, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 4 applications: ICC, IHC, Immunoprecipitation, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using MAB8094	Applications	Species
The, E;Zhai, Y;Yao, Q;Ao, L;Fullerton, DA;Meng, X; Molecular Interaction of Soluble Klotho with FGF23 in the Pathobiology of Aortic Valve Lesions Induced by Chronic Kidney Disease International journal of biological sciences 2024-06-17 [PMID: 38993571] (Western Blot, Human)	Western Blot	Human
Yue Gao, Shicheng Fan, Hua Li, Yiming Jiang, Xinpeng Yao, Shuguang Zhu et al. Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation Acta Pharmaceutica Sinica B 3/1/2021 [PMID: 33777678]
Maha Guimei, Sana Alrouh, Maha Saber-Ayad, Shirin A Hafezi, Arya Vinod, Surendra Rawat et al. <p>Inhibition of Yes-Associated Protein-1 (YAP1) Enhances the Response of Invasive Breast Cancer Cells to the Standard Therapy</p> Breast Cancer: Targets and Therapy 11/2/2020 [PMID: 33173331]
S Ono, K Nakano, K Takabatake, H Kawai, H Nagatsuka Immunohistochemistry of YAP and dNp63 and survival analysis of patients bearing precancerous lesion and oral squamous cell carcinoma Int J Med Sci, 2019-05-28;16(5):766-773. 2019-05-28 [PMID: 31217745] (IHC, Human)	IHC	Human
SS Islam, M Uddin, ASM Noman, H Akter, NJ Dity, M Basiruzzma, F Uddin, J Ahsan, S Annoor, AA Alaiya, M Al-Alwan, H Yeger, WA Farhat Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1 EBioMedicine, 2019-05-10;0(0):. 2019-05-10 [PMID: 31085100] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Y Yang, J Ren, Y Sun, Y Xue, Z Zhang, A Gong, B Wang, Z Zhong, Z Cui, Z Xi, GY Yang, Q Sun, L Bian A connexin43/YAP axis regulates astroglial-mesenchymal transition in hemoglobin induced astrocyte activation Cell Death Differ., 2018-06-07;0(0):. 2018-06-07 [PMID: 29880858] (Immunoprecipitation, Rat)	Immunoprecipitation	Rat

Array MAB8094

• YAP1 Antibodies
• YAP1 Proteins