XAF1 Antibody

The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-56355	Applications	Species
Zhu C, Li B, Frontzek K et al. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease J. Exp. Med. 2019-04-01 [PMID: 30842236] (WB, Mouse)	WB	Mouse
Lunardi A, Ala U, Epping MT et al. A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nat Genet. 2013-07-01 [PMID: 23727860]
Kempkensteffen Carsten, Fritzsche Florian Rudolf, Johannsen Manfred et al. Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer. BMC Cancer. 2009-01-01 [PMID: 19664236] (IF/IHC, Human)	IF/IHC	Human
Straszewski-Chavez SL, Visintin IP, Karassina N et al. XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway. J Biol Chem. 2007-04-27 [PMID: 17329253]
Xia Y, Novak R, Lewis J et al. Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP. Mol Cell Biochem. 2006-06-01 [PMID: 16432762] (WB)	WB
Wang X, Zhu C, Wang X et al. X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia. Neurobiol Dis. 2004-06-01 [PMID: 15207275] (IHC-P, Mouse)	IHC-P	Mouse

Array NB100-56355

• XAF1 Antibodies
• XAF1 Lysate
• XAF1 Proteins