Name: HTRA2/Omi Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF1458
Rating: 4.3 (3 reviews)

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, Simple Western, ICC/IF
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Formulation	Size	Price
Carrier Free AF1458-SP

Immunogen	E. coli-derived recombinant human HTRA2/Omi Ala134-Glu458 Accession # O43464
Specificity	Detects human, mouse, and rat full length and mitochondria-processed HTRA2/Omi.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	HTRA2
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

HTRA2/Omi Antibody [Unconjugated]

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Publications for HTRA2/Omi Antibody (AF1458)(33)

Reviews for HTRA2/Omi Antibody (AF1458) (3) 4.33

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Publications using AF1458	Applications	Species
Aishwarya, R;Abdullah, CS;Remex, NS;Bhuiyan, MAN;Lu, XH;Dhanesha, N;Stokes, KY;Orr, AW;Kevil, CG;Bhuiyan, MS; Diastolic dysfunction in Alzheimer's disease model mice is associated with A?-amyloid aggregate formation and mitochondrial dysfunction Scientific reports 2024-07-19 [PMID: 39030247] (Western Blot, Mouse)	Western Blot	Mouse
Jonas Wei beta , Michelle Heib, Thiemo Korn, Justus Hoyer, Johaiber Fuchslocher Chico, Susann Voigt et al. Protease-independent control of parthanatos by HtrA2/Omi Cellular and Molecular Life Sciences 9/1/2023 [PMID: 37594630]
R Aishwarya, S Alam, CS Abdullah, M Morshed, SS Nitu, M Panchatcha, S Miriyala, CG Kevil, MS Bhuiyan Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes Redox Biol, 2020-07-26;36(0):101660. 2020-07-26 [PMID: 32750667] (Western Blot, Rat)	Western Blot	Rat
ÉM Szeg?, A Dominguez-, E Gerhardt, A König, DJ Koss, W Li, R Pinho, C Fahlbusch, M Johnson, P Santos, A Villar-Piq, T Thom, S Rizzoli, M Schmitz, J Li, I Zerr, J Attems, O Jahn, TF Outeiro Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies Cell Rep, 2019-07-02;28(1):65-77.e6. 2019-07-02 [PMID: 31269451] (Western Blot, Rat)	Western Blot	Rat
Leisl M. Packer, Samantha J. Stehbens, Vanessa F. Bonazzi, Jennifer H. Gunter, Robert J. Ju, Micheal Ward et al. Bcl‐2 inhibitors enhance FGFR inhibitor‐induced mitochondrial‐dependent cell death in FGFR2‐mutant endometrial cancer Molecular Oncology 4/1/2019 [PMID: 30537101]
Taher Darreh-Shori, Sareh Rezaeianyazdi, Erica Lana, Sumonto Mitra, Anna Gellerbring, Azadeh Karami et al. Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer’s Disease Brain Molecular Neurobiology 7/1/2019 [PMID: 30361890]
Amy E. Vincent, Hannah S. Rosa, Kamil Pabis, Conor Lawless, Chun Chen, Anne Grünewald et al. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle Annals of Neurology 8/21/2018 [PMID: 30014514]
F Lampert, D Stafa, A Goga, MV Soste, S Gilberto, N Olieric, P Picotti, M Stoffel, M Peter The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation Elife, 2018-06-18;7(0):. 6/18/2018 [PMID: 29911972]
S Saita, H Nolte, KU Fiedler, H Kashkar, AS Venne, RP Zahedi, M Krüger, T Langer PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis Nat. Cell Biol, 2017-03-13;0(0):. 2017-03-13 [PMID: 28288130] (Western Blot, Human)	Western Blot	Human
Wu J, Li M, Cao L, Sun M, Chen D, Ren H, Xia Q, Tao Z, Qin Z, Hu Q, Wang G Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice. Acta Pharmacol Sin, 2015-08-24;36(9):1043-52. 2015-08-24 [PMID: 26299953] (Western Blot, Mouse)	Western Blot	Mouse
Ma Q, Hu Q, Xu R, Zhen X, Wang G Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1. Acta Pharmacol Sin, 2015-08-01;36(8):966-75. 2015-08-01 [PMID: 26238290] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
Morey T, Roufayel R, Johnston D, Fletcher A, Mosser D Heat shock inhibition of CDK5 increases NOXA levels through miR-23a repression. J Biol Chem, 2015-03-31;290(18):11443-54. 2015-03-31 [PMID: 25829494] (Western Blot, Human)	Western Blot	Human
Patterson , Victoria, Zullo , Alfred J, Koenig , Claire, Stoessel , Sean, Jo , Hakryul, Liu , Xinran, Han , Jinah, Choi , Murim, DeWan , Andrew T, Thomas , Jean-Leo, Kuan , Chia-Yi, Hoh , Josephin Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1. PLoS ONE, 2014-12-22;9(12):e115789. 2014-12-22 [PMID: 25531304] (Western Blot, Mouse)	Western Blot	Mouse
Aerts L, Craessaerts K, de Strooper B, Morais V PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402. J Biol Chem, 2014-12-19;290(5):2798-811. 2014-12-19 [PMID: 25527497] (Western Blot, Human)	Western Blot	Human
Yoshizumi T, Ichinohe T, Sasaki O, Otera H, Kawabata S, Mihara K, Koshiba T Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity. Nat Commun, 2014-08-20;5(0):4713. 2014-08-20 [PMID: 25140902] (Western Blot, Human)	Western Blot	Human
Xu R, Hu Q, Ma Q et al. The protease Omi regulates mitochondrial biogenesis through the GSK3B/PGC-1a pathway Cell Death Dis 8/14/2014 [PMID: 25118933]
Geisler S, Vollmer S, Golombek S, Kahle P The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy. J Cell Sci, 2014-06-06;127(0):3280-93. 2014-06-06 [PMID: 24906799] (ICC, Human)	ICC	Human
Yamauchi S, Hou Y, Guo A, Hirata H, Nakajima W, Yip A, Yu C, Harada I, Chiam K, Sawada Y, Tanaka N, Kawauchi K p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion. J Cell Biol, 2014-03-24;204(7):1191-207. 2014-03-24 [PMID: 24662565] (IHC, Mouse)	IHC	Mouse
Jin , Seok Min, Youle , Richard The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria. Autophagy, 2013-09-05;9(11):1750-7. 2013-09-05 [PMID: 24149988] (Western Blot, Human)	Western Blot	Human
Yamano , Koji, Youle , Richard PINK1 is degraded through the N-end rule pathway. Autophagy, 2013-04-17;9(11):1758-69. 2013-04-17 [PMID: 24121706] (Western Blot, Human)	Western Blot	Human
Hideyuki Yoshioka, Masataka Katsu, Hiroyuki Sakata, Nobuya Okami, Takuma Wakai, Hiroyuki Kinouchi et al. The Role of Parl and HtrA2 in Striatal Neuronal Injury After Transient Global Cerebral Ischemia Journal of Cerebral Blood Flow & Metabolism 11/1/2013 [PMID: 23921894]
Mariaelena Repici, Kornelis R. Straatman, Nadia Balduccio, Francisco J. Enguita, Tiago F. Outeiro, Flaviano Giorgini Parkinson’s disease-associated mutations in DJ-1 modulate its dimerization in living cells Journal of Molecular Medicine 5/1/2013 [PMID: 23183826]
Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol., 2010-01-24;12(2):119-31. 2010-01-24 [PMID: 20098416] (ICC, Human)	ICC	Human
Johnson F, Kaplitt MG Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders. PLoS ONE, 2009-09-18;4(9):e7100. 2009-09-18 [PMID: 19763263] (Western Blot, Human)	Western Blot	Human
Ding X, Patel M, Shen D, Herzlich AA, Cao X, Villasmil R, Klupsch K, Tuo J, Downward J, Chan CC Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration. Invest. Ophthalmol. Vis. Sci., 2009-05-14;50(10):4957-66. 2009-05-14 [PMID: 19443712] (ICC, IHC-Fr, Human, Mouse)	ICC, IHC-Fr	Human, Mouse
Oka T, Sayano T, Tamai S, Yokota S, Kato H, Fujii G, Mihara K Identification of a novel protein MICS1 that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c. Mol. Biol. Cell, 2008-04-16;19(6):2597-608. 2008-04-16 [PMID: 18417609] (ICC, Human)	ICC	Human
Huttunen HJ, Guenette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J. Biol. Chem., 2007-08-06;282(38):28285-95. 2007-08-06 [PMID: 17684015] (ICC, Western Blot, Hamster)	ICC, Western Blot	Hamster
Grobner S, Autenrieth SE, Soldanova I, Gunst DS, Schaller M, Bohn E, Muller S, Leverkus M, Wesselborg S, Autenrieth IB, Borgmann S Yersinia YopP-induced apoptotic cell death in murine dendritic cells is partially independent from action of caspases and exhibits necrosis-like features. Apoptosis, 2006-11-01;11(11):1959-68. 2006-11-01 [PMID: 17036200] (Western Blot, Mouse)	Western Blot	Mouse
Gomez-Vicente V, Doonan F, Donovan M, Cotter TG Induction of BIM(EL) following growth factor withdrawal is a key event in caspase-dependent apoptosis of 661W photoreceptor cells. Eur. J. Neurosci., 2006-08-01;24(4):981-90. 2006-08-01 [PMID: 16930425] (ICC, Mouse)	ICC	Mouse
Wang H, Jiang JY, Zhu C, Peng C, Tsang BK Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia. Mol. Endocrinol., 2006-05-18;20(10):2469-82. 2006-05-18 [PMID: 16709598] (Western Blot, Rat)	Western Blot	Rat
Wesierska-Gadek J, Gueorguieva M, Horky M Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. Mol. Cancer Ther., 2005-01-01;4(1):113-24. 2005-01-01 [PMID: 15657359] (ICC, Human)	ICC	Human
Kevin M. Wright, Michael W. Linhoff, Patrick Ryan Potts, Mohanish Deshmukh Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis The Journal of Cell Biology 10/25/2004 [PMID: 15504912]
Perrelet D, Perrin FE, Liston P, Korneluk RG, MacKenzie A, Ferrer-Alcon M, Kato AC Motoneuron resistance to apoptotic cell death in vivo correlates with the ratio between X-linked inhibitor of apoptosis proteins (XIAPs) and its inhibitor, XIAP-associated factor 1. J. Neurosci., 2004-04-14;24(15):3777-85. 2004-04-14 [PMID: 15084658] (Western Blot, Rat)	Western Blot	Rat
Show All 33 Publications. Collapse Publications.

	Verified Customer 06/07/2017
Application:	ICC
Species:	Pig

	Verified Customer 06/07/2017
Application:	ICC
Species:	Pig

	Verified Customer 01/05/2015
Application:	IF
Species:	Human

Gene Symbol	HTRA2
Uniprot	O43464()