XAF1 Products

Description

X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001 [PubMed 11175744]).[supplied by OMIM]

Bioinformatics

Entrez	54739 Human
Uniprot	CAA68030 Human NM_017523 Human NP_059993 Human NP_059993.2 Human Q6GPH4 Human
Product By Gene ID	54739
Alternate Names	BIRC4-binding protein BIRC4BPBIRC4 binding protein HSXIAPAF1 XIAP associated factor 1 XIAPAF1XIAP-associated factor 1

Research Areas for XAF1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis