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Vitronectin Antibody (A18) [PerCP]

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Product Details

Summary
Reactivity Bv, Eq, RbSpecies Glossary
Applications ELISA, IHC, WB (-)
Clone
A18
Clonality
Monoclonal
Host
Mouse
Conjugate
PerCP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-23571AF350
Alexa Fluor 532
NBP2-23571AF532
Alexa Fluor 594
NBP2-23571AF594
Alexa Fluor 750
NBP2-23571AF750
DyLight 594
NBP2-23571DL594
Unconjugated
NBP2-23571
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-23571
BSA Free
NBP2-23571
BSA Free
NBP2-23571-0.05mg
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Vitronectin Antibody (A18) [PerCP] Summary

Immunogen
Lysed bovine corneal endothelial cells and extracellular matrix
Epitope
Not determined
Specificity
Highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). The antibody inhibits integrin-mediated cell adhesion to bovine vitronectin. It can be used to probe vitronectin conformation.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
VTN
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Vitronectin Antibody (A18) [PerCP]

  • Complement S-protein
  • epibolin
  • Serum Spreading Factor
  • Serum-spreading factor
  • Somatomedin B
  • S-protein
  • V75
  • vitronectin (serum spreading factor, somatomedin B, complement S-protein)
  • Vitronectin
  • VN
  • VNT
  • VTN

Background

Vitronectin also called serum spreading factor or complement S-protein, is a member of the pexin family (1). Found in serum and in tissues, Vitronectin exist in two forms; as a single chain (75kDa) and as a clipped form composed of two chains (65kDa and 10kDa). Vitronectin promotes cell adhesion, spreading and migration through specific interactions with cellular integrins, and inhibits cytolysis by the complement C5b-9 complex (2-4). Vitronectin also interacts with several critical proteins that regulate thrombosis and fibrinolysis. Vitronectin is phosphorylated by PKA and CKII (5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol VTN