Vanilloid R1/TRPV1 Antibody

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. FUNCTION: Receptor-activated non-selective calcium permanent cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Rat, Porcine.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-98897	Applications	Species
Madeo M, Colbert PL, Vermeer DW et al. Cancer exosomes induce tumor innervation. Nat Commun. 2018-10-16 [PMID: 30327461] (WB, Human)	WB	Human
Yoshie K, Rajendran PS, Massoud L et al. Cardiac Vanilloid Receptor-1 Afferent Depletion Enhances Stellate Ganglion Neuronal Activity and Efferent Sympathetic Response to Cardiac Stress Am. J. Physiol. Heart Circ. Physiol. 2018-01-16 [PMID: 29351450] (Porcine)		Porcine
Wen W, Que K, Zang C et al. Expression and distribution of three transient receptor potential vanilloid(TRPV) channel proteins in human odontoblast-like cells J. Mol. Histol. 2017-09-13 [PMID: 28905239] (IF/IHC, Human)	IF/IHC	Human
Issa AT, Miyata K, Heng V, Mitchell KD, Derbenev AV. Increased neuronal activity in the OVLT of Cyp1a1-Ren2 transgenic rats with inducible Ang II-dependent malignant hypertension. Neurosci Lett. 2012-05-08 [PMID: 22579820] (WB, Rat)	WB	Rat

Array NB100-98897

• Vanilloid R1/TRPV1 Antibodies
• Vanilloid R1/TRPV1 ELISA Kits
• Vanilloid R1/TRPV1 Lysates
• Vanilloid R1/TRPV1 Proteins