Vanilloid R1/TRPV1 Antibody

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. FUNCTION: Receptor-activated non-selective calcium permanent cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IHC, WB.

Showing Publications 1 - 7 of 7.

Publications using NB100-98886	Applications	Species
Huerta TS, Haider B, Adamovich-Zeitlin R et al. Calcium imaging and analysis of the jugular-nodose ganglia enables identification of distinct vagal sensory neuron subsets Journal of neural engineering 2023-03-15 [PMID: 36920156] (IHC, Mouse)	IHC	Mouse
Kiss F, Kormos V, Szoke E et al. Functional Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Ion Channels Are Overexpressed in Human Oral Squamous Cell Carcinoma International journal of molecular sciences 2022-02-08 [PMID: 35163843]
Wang X, Yang XL, Kong WL et al. TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain J Neuroinflammation 2019-11-13 [PMID: 31722723] (WB, ICC/IF, Mouse)	WB, ICC/IF	Mouse
Kong W, Wang X, Yang X et al. Activation of TRPV1 Contributes to Recurrent Febrile Seizures via Inhibiting the Microglial M2 Phenotype in the Immature Brain Front. Cell. Neurosci. 2019-10-11 [PMID: 31680864] (IF/IHC, Mouse)	IF/IHC	Mouse
Matulonis UA, Hirsch M, Palescandolo E et al. High throughput interrogation of somatic mutations in high grade serous cancer of the ovary. PLoS One 2011-01-01 [PMID: 21931712] (Human)		Human
Wood P, Mulay V, Darabi M, et al. Ras/mitogen-activated protein kinase (MAPK) signaling modulates protein stability and cell surface expression of scavenger receptor SR-BI J Biol Chem 2011-07-01 [PMID: 21525007]
Qi J, Buzas K, Fan H, Cohen J et al. Painful pathways induced by TLR stimulation of dorsal root ganglion neurons J Immunol 2011-06-01 [PMID: 21515789] (WB, IF/IHC, ICC/IF, Human, Mouse)	WB, IF/IHC, ICC/IF	Human, Mouse

Array NB100-98886

• Vanilloid R1/TRPV1 Antibodies
• Vanilloid R1/TRPV1 ELISA Kits
• Vanilloid R1/TRPV1 Lysates
• Vanilloid R1/TRPV1 Proteins