Western Blot: UBR4 Antibody [NBP1-28730] - Whole cell lysate from NIH3T3, TCMK-1, 4T1, and CT26.WT cells.
Immunohistochemistry-Paraffin: UBR4 Antibody [NBP1-28730] - Section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- p600 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Independent Antibodies: Immunoprecipitation: UBR4 Antibody [NBP1-28730] - Detection of Human p600 on HeLa whole cell lysate using NBP28730. p600 was also immunoprecipitated by rabbit anti-p600 antibodies ...read more
The immunogen recognized by this antibody maps to a region between residue 1350 and 1400 of human retinoblastoma-associated factor 600 using the numbering given in entry NP_065816.1 (GeneID 23352).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
UBR4
Purity
Immunogen affinity purified
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ubiquitin protein ligase E3 component n-recognin 4
Zinc finger UBR1-type protein 1
ZUBR1retinoblastoma-associated factor 600-like protein
Background
p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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