UBR4 Products

Description

p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions.

Bioinformatics

Entrez	23352 Human
Uniprot	NP_065816 Human NP_065816.2 Human Q5T4S7 Human
Product By Gene ID	23352
Alternate Names	600 kDa retinoblastoma protein-associated factor EC 6.3.2 EC 6.3.2.- KIAA0462E3 ubiquitin-protein ligase UBR4 KIAA1307zinc finger, UBR1 type 1 N-recognin-4 p600 RBAF600FLJ41863 Retinoblastoma-associated factor of 600 kDa ubiquitin protein ligase E3 component n-recognin 4 Zinc finger UBR1-type protein 1 ZUBR1retinoblastoma-associated factor 600-like protein