Triadin Antibody

The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR®s) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR®s), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, Triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR®s and RyR®s. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.

Showing Publications 1 - 2 of 2.

Publications using NBP1-87417	Applications	Species
Masashi Ogasawara, Megumu Ogawa, Ikuya Nonaka, Shinichiro Hayashi, Satoru Noguchi, Ichizo Nishino Evaluation of the Core Formation Process in Congenital Neuromuscular Disease With Uniform Type 1 Fiber and Central Core Disease. Journal of neuropathology and experimental neurology 2021-03-05 [PMID: 33184643]
Engel AG, Redhage KR, Tester DJ et al. Congenital myopathy associated with the triadin knockout syndrome. Neurology. 2017-02-15 [PMID: 28202702] (IHC-P, Human)	IHC-P	Human

Array NBP1-87417

• Triadin Antibodies
• Triadin Proteins