CACNA1S Antibody (1A) - BSA Free

Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling.The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: FLOW, IF/IHC, WB.

Showing Publications 1 - 2 of 2.

Publications using NB300-542	Applications	Species
Sarute N, Ross SR CACNA1S haploinsufficiency confers resistance to New World arenavirus infection Proc. Natl. Acad. Sci. U.S.A. 2020-08-11 [PMID: 32719120] (FLOW, WB, Mouse, Human)	FLOW, WB	Mouse, Human
Vihola A, Sirito M, Bachinski LL et al. Altered expression and splicing of Ca(2+) metabolism genes in myotonic dystrophies DM1 and DM2. Neuropathol Appl Neurobiol 2012-07-03 [PMID: 22758909] (WB, IF/IHC, Human)	WB, IF/IHC	Human

Array NB300-542

• CACNA1S Antibodies
• CACNA1S Proteins