TIRAP Antibody

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB100-2823	Applications	Species
Farina C, Krumbholz M, Giese T et al. Preferential expression and function of Toll-like receptor 3 in human astrocytes. J Neuroimmunol 2005-02-01 [PMID: 15652398]

Array NB100-2823

• TIRAP Antibodies
• TIRAP ELISA Kits
• TIRAP Protein