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TGF-beta RI/ALK-5 Antibody (141229)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clone
141229
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price
Carrier Free
MAB587-SP
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TGF-beta RI/ALK-5 Antibody (141229) Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TGF‑ beta  RI/ALK-5
Ala21-Glu121
Accession # BAA05023
Specificity
Detects mouse TGF‑ beta  RI/ALK-5 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody shows approximately 20‑25% cross-reactivity with recombinant human (rh) TGF-beta RI and no cross-reactivity with recombinant rat MIS RII, rhTGF-beta RII, rhTGF‑ beta  RIIb, or rhTGF‑ beta  RIII.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
TGFBR1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB587 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF-beta RI/ALK-5 Antibody (141229)

  • AAT5
  • activin A receptor type II-like kinase, 53kD
  • activin A receptor type II-like kinase, 53kDa
  • Activin receptor-like kinase 5
  • ACVRLK4
  • ALK-5
  • ALK-5ALK5
  • EC 2.7.11
  • EC 2.7.11.30
  • LDS1A
  • LDS2A
  • Serine/threonine-protein kinase receptor R4
  • SKR4
  • tbetaR-I
  • TGFB1R1
  • TGF-beta receptor type I
  • TGF-beta receptor type-1
  • TGF-beta RI
  • TGF-beta type I receptor
  • TGFbetaRI
  • TGFBR1
  • TGF-bRI
  • TGFR-1
  • transforming growth factor beta receptor I
  • transforming growth factor, beta receptor 1
  • transforming growth factor, beta receptor I (activin A receptor type II-likekinase, 53kD)
  • Transforming growth factor-beta receptor type I

Background

Most cell types express three sizes of receptors for TGF-beta . These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor, originally known as ALK-5 (Activin receptor‑like kinase) is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta . Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.
  1. Miyazono, K. et al. (1994) Adv. In Immunol. 55:181.
  2. Massagùe, J. (1998) Ann. Rev. Biochem. 67:753.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TGF-beta RI/ALK-5 Antibody (MAB587)(2)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.


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Bioinformatics

Gene Symbol TGFBR1
Uniprot