TDP-43/TARDBP Antibody (671834) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TDP-43 (TAR DNA binding protein of 43 kDa; gene name TARDBP) is a 414 amino acid (aa) nuclear RNA/DNA binding phosphoprotein that regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 20-28 kDa form, in ubiquitin-containing inclusion bodies. TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis. Within aa 1-103, human and mouse TDP-43 share 100% aa sequence identity, and 99% aa identity with rat TDP-43.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 6 of 6.

Publications using MAB7778	Applications	Species
Worrall, D;Ayoubi, R;Fotouhi, M;Southern, K;McPherson, PS;Laflamme, C;NeuroSGC/YCharOS/EDDU collaborative group, ;ABIF Consortium, ; The identification of high-performing antibodies for TDP-43 for use in Western Blot, immunoprecipitation and immunofluorescence F1000Research 2023-06-20 [PMID: 37359785] (Western Blot, Human)	Western Blot	Human
T Feng, L Luan, II Katz, M Ullah, VM Van Deerli, JQ Trojanowsk, EB Lee, F Hu TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss Acta neuropathologica communications, 2022-03-14;10(1):33. 3/14/2022 [PMID: 35287730]
K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids Stem Cell Reports, 2022-03-03;0(0):. 2022-03-03 [PMID: 35245440] (Western Blot, Mouse)	Western Blot	Mouse
Devoy A, Price G, De Giorgio F Et al. Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models iScience 12/1/2021 [PMID: 34988393]
Koji Matsukawa, Michail S. Kukharsky, Sei-Kyoung Park, Sangeun Park, Naruaki Watanabe, Takeshi Iwatsubo et al. Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy RNA Biology 2021-11-02 [PMID: 33427561]
Feng T, Mai S, Roscoe JM et al. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice EMBO Rep. 8/10/2020 [PMID: 32852886]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	IHC-P	Human brain cortex-formalin fixed paraffin embedded	10/25/2018	View Summary Application Immunohistochemistry-Paraffin Sample Tested Paraffin section of human brain Species Human brain cortex-formalin fixed paraffin embedded Lot CHGW011806A Comments Comments Antigen retrieval performed-Heat mediated at pH9 Concentration: 1 in 100 overnight at 4C Secondary antibody: Alexafluor 594 anti-mouse antibody (Thermo) at 1 in 250 Primary and secondary antibodies prepared in Antibody Diluent/ background reducing from Agilent.

Array MAB7778

• TDP-43/TARDBP Antibodies
• TDP-43/TARDBP ELISA Kits
• TDP-43/TARDBP Lysate
• TDP-43/TARDBP Proteins
• TDP-43/TARDBP Proteins and Enzyme