TDP-43/TARDBP Antibody (3H8)

TARDBP (tar-DNA binding protein of 43) is a nucleic acids binding protein that regulates the process of transcription and splicing. Localized mainly in the nucleus, TARDBP is ubiquitously expressed with higher expression levels in pancreas, placenta, lung, genital tract and spleen, and has been suggested to implicate in microRNA biogenesis, cellular apoptosis as well as proliferation. TARDBP controls CFTR splicing and promotes CFTR exon 9 skipping by associating with UG repeated motifs in polymorphic region near 3'-splice site of this exon leading to aberrant splicing linked to pathological features typical of cystic fibrosis. TARDBP can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Moreover, it stabilizes the low molecular weight neurofilament mRNA through a direct interaction with the 3' UTR. TARDBP was originally identified as a major protein component of the ubiquitin immuno-positive inclusions which are the pathologic substrate of common forms of ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), and later, it was found that TARDBP gene mutations are inherited in an autosomal dominant manner in familial/sporadic ALS. TARDBP has also been involved in other neurodegenerative such as Alzheimer's and Parkinson's disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, WB.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IHC-Fr, WB.

Showing Publications 1 - 6 of 6.

Publications using NBP1-92695	Applications	Species
Worrall, D;Ayoubi, R;Fotouhi, M;Southern, K;McPherson, PS;Laflamme, C;NeuroSGC/YCharOS/EDDU collaborative group, ;ABIF Consortium, ; The identification of high-performing antibodies for TDP-43 for use in Western Blot, immunoprecipitation and immunofluorescence F1000Research 2023-06-20 [PMID: 37359785] (WB)	WB
Evangelista B, Cahalan S, Ragusa J et al. Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates iScience 2023-05-01 [PMID: 37182104] (WB, WB)	WB	WB
Kiryu-Seo S, Matsushita R, Tashiro Y et al. Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons The EMBO journal 2022-08-25 [PMID: 36004759] (IHC-Fr, Mouse) Details: Dilutions: 1:500	IHC-Fr	Mouse
De Rossi P, Lewis AJ, Furrer J Et al. FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade EMBO reports 2021-11-22 [PMID: 34806807] (IF/IHC, Human)	IF/IHC	Human
Maatta TA, Rettel M, Sridharan S et al. Aggregation and disaggregation features of the human proteome Mol Syst Biol 2020-10-01 [PMID: 33022891] (ICC/IF, Human)	ICC/IF	Human
Verbeeck C, Deng Q, Dejesus-Hernandez M et al. Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis Mol Neurodegener 2012-10-10 [PMID: 23046583] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse

Array NBP1-92695

• TDP-43/TARDBP Antibodies
• TDP-43/TARDBP ELISA Kits
• TDP-43/TARDBP Lysate
• TDP-43/TARDBP Proteins
• TDP-43/TARDBP Proteins and Enzyme