TBX5 Antibody (1G10)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using H00006910-M01	Applications	Species
L Drakhlis, S Biswanath, CM Farr, V Lupanow, J Teske, K Ritzenhoff, A Franke, F Manstein, E Bolesani, H Kempf, S Liebscher, K Schenke-La, J Hegermann, L Nolte, H Meyer, J de la Roch, S Thiemann, C Wahl-Schot, U Martin, R Zweigerdt Human heart-forming organoids recapitulate early heart and foregut development Nature Biotechnology, 2021-02-08;0(0):. 2021-02-08 [PMID: 33558697]
Ghosh T, Aparicio-Sanchez J, Buxton S et al. HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1. Sci Rep. 2019-11-29 [PMID: 31784580]
Baban A, Pitto L, Pulignani S et al. Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: Functional characterization of a de novo TBX5 mutation. Am J Med Genet A. 2014-03-24 [PMID: 24664498]
Hartung S, Schwanke K, Haase A et al. Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors. Stem Cells Dev. 2013-01-18 [PMID: 23157212]
Ghosh TK, Song FF, Packham EA et al. Physical interaction between TBX5 MEF2C is required for early heart development. Mol Cell Biol 29(8):2205-18. 2009-04-01 [PMID: 19204083]
Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018-01-01

Array H00006910-M01

• TBX5 Antibodies
• TBX5 Lysates
• TBX5 Proteins