Recombinant Human FGF-10 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal, and epithelial origin. FGF-10 belongs to the subgroup of FGFs that also includes FGF-3, -7, and -22 (1). Mature human FGF-10 is an approximately 20 kDa protein that contains a serine-rich region near its N-terminus (2, 3). It shares 93% and 96% amino acid sequence identity with mouse and rat FGF-10, respectively. FGF-10 is secreted by mesenchymal cells and associates with extracellular FGF-BP (1, 4). It preferentially binds and activates epithelial cell FGF R2 (IIIb) and interacts more weakly with FGF R1 (IIIb) (5). The mitogenic and chemotactic properties of FGF-10 are critical in many tissues during embryogenesis. This includes limb bud initiation (6), palate development (7), branching morphogenesis and directional outgrowth of lung buds (8, 9), formation of the otic vesicle and chochlea (10), adipogenesis (11), and the development of prostate, mammary, lacrimal, and submandibular salivary glands (12 - 15). FGF R2 (IIIb) signaling in these responsive tissues is similarly important during embryogenesis (7, 10, 13 ‑ 15). The expression and function of FGF-10 are negatively regulated by Shh and BMP-4 in the developing lung (8, 9). Overlapping expression patterns and activities with FGF-3, -7,  and -8 suggest at least a partial redundancy in FGF‑10 biology (7, 10, 14, 15). FGF-10 induced signaling through FGF R2 (IIIb) also contributes to the progression of pancreatic cancer (16).

We have publications tested in 8 confirmed species: Human, Mouse, Canine, Chicken, Macaca mulatta (Rhesus Macaque), Transgenic Mouse, Xenopus, Zebrafish.

We have publications tested in 4 applications: Binding Assay, Bioassay, Cell Culture, In Vivo.

Showing Publications 1 - 10 of 103. Show All 103 Publications. Collapse Publications.

Publications using 345-FG	Applications	Species
Peak, KE;Rajaguru, P;Khan, A;Gleghorn, JP;Obaid, G;Ferruzzi, J;Varner, VD; Photo-induced changes in tissue stiffness alter epithelial budding morphogenesis in the embryonic lung bioRxiv : the preprint server for biology 2024-08-26 [PMID: 39229009] (Bioassay, Chicken)	Bioassay	Chicken
Chen, Y;Mu, W;Wu, Y;Xu, J;Li, X;Hu, H;Wang, S;Wang, D;Hui, B;Wang, L;Dong, Y;Chen, W; Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei Journal of tissue engineering 2024-07-31 [PMID: 39092452] (Bioassay, Human)	Bioassay	Human
Zhang, R;Chen, Y;Feng, Z;Cai, B;Cheng, Y;Du, Y;Ou, S;Chen, H;Pan, M;Liu, H;Pei, D;Cao, S; Reprogramming human urine cells into intestinal organoids with long-term expansion ability and barrier function Heliyon 2024-07-15 [PMID: 39040281] (Bioassay, Human)	Bioassay	Human
Donahue, KL;Watkoske, HR;Kadiyala, P;Du, W;Brown, K;Scales, MK;Elhossiny, AM;Espinoza, CE;Lasse Opsahl, EL;Griffith, BD;Wen, Y;Sun, L;Velez-Delgado, A;Renollet, NM;Morales, J;Nedzesky, NM;Baliira, RK;Menjivar, RE;Medina-Cabrera, PI;Rao, A;Allen, B;Shi, J;Frankel, TL;Carpenter, ES;Bednar, F;Zhang, Y;Pasca di Magliano, M; Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth Cancer discovery 2024-07-03 [PMID: 38958646] (Bioassay, Human)	Bioassay	Human
Schäfer, TE;Knol, LI;Haas, FV;Hartley, A;Pernickel, SCS;Jády, A;Finkbeiner, MSC;Achberger, J;Arelaki, S;Modic, Ž;Schröer, K;Zhang, W;Schmidt, B;Schuster, P;Haferkamp, S;Doerner, J;Gebauer, F;Ackermann, M;Kvasnicka, HM;Kulkarni, A;Bots, STF;Kemp, V;Hawinkels, LJAC;Poetsch, AR;Hoeben, RC;Ehrhardt, A;Marchini, A;Ungerechts, G;Ball, CR;Engeland, CE; Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures EBioMedicine 2024-06-27 [PMID: 38941955] (Bioassay, Human)	Bioassay	Human
Nipper, M;Xu, Y;Liu, J;Yin, X;Liu, Z;Ye, Z;Zhang, J;Chen, Y;Wang, P; TGF? and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas Cells 2024-01-18 [PMID: 38247878] (Cell Culture, Human)	Cell Culture	Human
Li, C;Liu, Z;Anderson, J;Liu, Z;Tang, L;Li, Y;Peng, N;Chen, J;Liu, X;Fu, L;Townes, TM;Rowe, SM;Bedwell, DM;Guimbellot, J;Zhao, R; Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells PloS one 2023-11-29 [PMID: 38019847] (Bioassay, Human)	Bioassay	Human
Yang, Y;McCullough, CG;Seninge, L;Guo, L;Kwon, WJ;Zhang, Y;Li, NY;Gaddam, S;Pan, C;Zhen, H;Torkelson, J;Glass, IA;Birth Defects Research Laboratory, ;Charville, G;Que, J;Stuart, J;Ding, H;Oro, A; A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa bioRxiv : the preprint server for biology 2023-10-26 [PMID: 37961271] (Bioassay, Human)	Bioassay	Human
Chen, HJ;Gardner, EE;Shah, Y;Zhang, K;Thakur, A;Zhang, C;Elemento, O;Varmus, H; FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS bioRxiv : the preprint server for biology 2023-10-09 [PMID: 37873210] (Bioassay, Human)	Bioassay	Human
Ito, I;Yousef, AMG;Chowdhury, S;Dickson, PN;Naini, ZA;White, MG;Fleten, KG;Flatmark, K;Fournier, KF;Fowlkes, NW;Shen, JP; Intraperitoneal paclitaxel is a safe and effective therapeutic strategy for treating mucinous appendiceal adenocarcinoma Cancer research 2023-07-11 [PMID: 37433032] (Bioassay, Human)	Bioassay	Human
Alber, AB;Marquez, HA;Ma, L;Kwong, G;Thapa, BR;Villacorta-Martin, C;Lindstrom-Vautrin, J;Bawa, P;Wang, F;Luo, Y;Ikonomou, L;Shi, W;Kotton, DN; Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme Nature communications 2023-06-13 [PMID: 37311756] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Matkovic Leko, I;Schneider, RT;Thimraj, TA;Schrode, N;Beitler, D;Liu, HY;Beaumont, K;Chen, YW;Snoeck, HW; A distal lung organoid model to study interstitial lung disease, viral infection and human lung development Nature protocols 2023-05-10 [PMID: 37165073] (Bioassay, Human)	Bioassay	Human
IM Leko, N Schrode, J Torres, M Pezet, TA Thimraj, KG Beaumont, HW Snoeck Generation and expansion of transitional lung organoids from human pluripotent stem cells bioRxiv : the preprint server for biology, 2023-02-01;0(0):. 2023-02-01 [PMID: 36778291] (Bioassay, Human)	Bioassay	Human
A Floerching, JE Klein, MSC Finkbeiner, TE Schäfer, G Fuchs, J Doerner, H Zirngibl, M Ackermann, HM Kvasnicka, KA Chester, D Jäger, CR Ball, G Ungerechts, CE Engeland A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectors Cell Death & Disease, 2023-02-10;14(2):104. 2023-02-10 [PMID: 36765035] (Bioassay, Human)	Bioassay	Human
J Tian, JH Chen, SX Chao, K Pelka, M Giannakis, J Hess, K Burke, V Jorgji, P Sindurakar, J Braverman, A Mehta, T Oka, M Huang, D Lieb, M Spurrell, JN Allen, TA Abrams, JW Clark, AC Enzinger, PC Enzinger, SJ Klempner, NJ McCleary, JA Meyerhardt, DP Ryan, MB Yurgelun, K Kanter, EE Van Sevent, I Baiev, G Chi, J Jarnagin, WB Bradford, E Wong, AG Michel, IJ Fetter, G Siravegna, AJ Gemma, A Sharpe, S Demehri, R Leary, CD Campbell, O Yilmaz, GA Getz, AR Parikh, N Hacohen, RB Corcoran Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial Nature Medicine, 2023-01-26;0(0):. 2023-01-26 [PMID: 36702949] (Bioassay, Human)	Bioassay	Human
G Parthasara, MB Pattison, CC Midkiff The FGF/FGFR system in the microglial neuroinflammation with Borrelia burgdorferi: likely intersectionality with other neurological conditions Journal of Neuroinflammation, 2023-01-17;20(1):10. 2023-01-17 [PMID: 36650549] (Bioassay, Macaca mulatta (Rhesus Macaque))	Bioassay	Macaca mulatta (Rhesus Macaque)
Y Sun, OY Revach, S Anderson, EA Kessler, CH Wolfe, A Jenney, CE Mills, EJ Robitschek, TGR Davis, S Kim, A Fu, X Ma, J Gwee, P Tiwari, PP Du, P Sindurakar, J Tian, A Mehta, AM Schneider, K Yizhak, M Sade-Feldm, T LaSalle, T Sharova, H Xie, S Liu, WA Michaud, R Saad-Beret, KB Yates, A Iracheta-V, JKE Spetz, X Qin, KA Sarosiek, G Zhang, JW Kim, MY Su, AM Cicerchia, MQ Rasmussen, SJ Klempner, D Juric, SI Pai, DM Miller, A Giobbie-Hu, JH Chen, K Pelka, DT Frederick, S Stinson, E Ivanova, AR Aref, CP Paweletz, DA Barbie, DR Sen, DE Fisher, RB Corcoran, N Hacohen, PK Sorger, KT Flaherty, GM Boland, RT Manguso, RW Jenkins Targeting TBK1 to overcome resistance to cancer immunotherapy Nature, 2023-01-12;0(0):. 2023-01-12 [PMID: 36634707] (Bioassay, Human)	Bioassay	Human
S Raad, A David, M Sagniez, B Paré, Z Orfi, NA Dumont, MA Smith, C Faure iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage Disease Models & Mechanisms, 2022-11-28;0(0):. 2022-11-28 [PMID: 36317486] (Bioassay, Human)	Bioassay	Human
H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Cell Stem Cell, 2022-10-06;29(10):1491-1504.e9. 2022-10-06 [PMID: 36206732] (Bioassay, Mouse)	Bioassay	Mouse
Y Han, L Tan, T Zhou, L Yang, L Carrau, LA Lacko, M Saeed, J Zhu, Z Zhao, BE Nilsson-Pa, FT Lira Neto, C Cahir, AM Giani, JC Chai, Y Li, X Dong, D Moroziewic, NYSCF Glob, D Paull, T Zhang, S Koo, C Tan, R Danziger, Q Ba, L Feng, Z Chen, A Zhong, GJ Wise, JZ Xiang, H Wang, RE Schwartz, BR tenOever, SA Noggle, CM Rice, Q Qi, T Evans, S Chen A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants Cell Stem Cell, 2022-10-06;29(10):1475-1490.e6. 2022-10-06 [PMID: 36206731] (Bioassay, Human)	Bioassay	Human
T Jiang, W Hu, S Zhang, C Ren, S Lin, Z Zhou, H Wu, J Yin, L Tan Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis Respiratory Research, 2022-10-01;23(1):269. 2022-10-01 [PMID: 36183124] (Cell Culture, Human)	Cell Culture	Human
MC Jaboreck, JL Lühmann, M Mielenz, F Stanke, G Göhring, U Martin, R Olmer, S Merkert Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line Stem Cell Research, 2022-09-14;64(0):102918. 2022-09-14 [PMID: 36162332] (Bioassay, Human)	Bioassay	Human
V Lungova, K Wendt, SL Thibeault Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling Oncogene, 2022-08-23;0(0):. 2022-08-23 [PMID: 35770504] (Bioassay, Human)	Bioassay	Human
A Chansaenro, C Adine, S Charoenlap, S Roytrakul, L Sariya, T Osathanon, S Rungarunle, G Urkasemsin, R Chaisupara, S Yodmuang, GR Souza, JN Ferreira Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair Bioactive materials, 2022-02-16;18(0):151-163. 2022-02-16 [PMID: 35387159] (Bioassay, Human)	Bioassay	Human
S Imamura, K Yoshimoto, S Terada, K Takamuro, KI Kamei In vitro culture at 39��C during hepatic maturation of human ES cells facilitates hepatocyte-like cell functions Scientific Reports, 2022-03-25;12(1):5155. 2022-03-25 [PMID: 35338220] (Bioassay, Human)	Bioassay	Human
AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (Bioassay, Human)	Bioassay	Human
L Johnson Ch, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudás, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fi, A Zine Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs International Journal of Molecular Sciences, 2021-10-07;22(19):. 2021-10-07 [PMID: 34639189] (Bioassay, Human)	Bioassay	Human
K Gkatzis, P Panza, S Peruzzo, DY Stainier Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures Elife, 2021-09-29;10(0):. 2021-09-29 [PMID: 34586063] (Bioassay, Mouse)	Bioassay	Mouse
Y Aghazadeh, F Poon, F Sarangi, FTM Wong, ST Khan, X Sun, R Hatkar, BJ Cox, SS Nunes, MC Nostro Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models Cell Stem Cell, 2021-09-03;0(0):. 2021-09-03 [PMID: 34480863] (Bioassay, Human)	Bioassay	Human
MO Lee, SG Lee, CR Jung, YS Son, JW Ryu, KB Jung, JH Ahn, JH Oh, HA Lee, JH Lim, J Kim, I Jang, J Choi, J Jung, K Park, B Lee, DS Kim, MY Son, HS Cho Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells Nature Communications, 2021-07-23;12(1):4492. 2021-07-23 [PMID: 34301945] (Bioassay, Human)	Bioassay	Human
AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D Nature Protocols, 2021-03-01;0(0):. 2021-03-01 [PMID: 33649566] (Bioassay, Human)	Bioassay	Human
H Tomita, K Tanaka, A Hirata, H Okada, H Imai, Y Shirakami, K Ohnishi, S Sugie, H Aoki, Y Hatano, K Noguchi, T Kanayama, A Niwa, N Suzui, T Miyazaki, T Tanaka, H Akiyama, M Shimizu, K Yoshida, A Hara Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas Cell Reports, 2021-02-23;34(8):108772. 2021-02-23 [PMID: 33626352] (Human)		Human
L Cui, J Zheng, Q Zhao, JR Chen, H Liu, G Peng, Y Wu, C Chen, Q He, H Shi, S Yin, RA Friedman, Y Chen, MX Guan Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss JCI Insight, 2020-12-03;5(23):. 2020-12-03 [PMID: 33268592] (Bioassay, Human)	Bioassay	Human
FJ Hawkins, S Suzuki, ML Beermann, C Barillà, R Wang, C Villacorta, A Berical, JC Jean, J Le Suer, T Matte, C Simone-Roa, Y Tang, TM Schlaeger, AM Crane, N Matthias, SXL Huang, SH Randell, J Wu, JR Spence, G Carraro, BR Stripp, A Rab, EJ Sorsher, A Horani, SL Brody, BR Davis, DN Kotton Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell, 2020-10-23;0(0):. 2020-10-23 [PMID: 33098807] (Bioassay, Human)	Bioassay	Human
J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Lindstrom-, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell, 2020-09-18;0(0):. 2020-09-18 [PMID: 32979316] (Bioassay, Human)	Bioassay	Human
MT Hoffman, SB Kemp, DJ Salas-Esca, Y Zhang, NG Steele, S The, D Long, S Benitz, W Yan, RF Margolskee, F Bednar, M Pasca di M, HJ Wen, HC Crawford The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice Cell Mol Gastroenterol Hepatol, 2020-08-31;0(0):. 2020-08-31 [PMID: 32882403] (Cell Culture, Mouse)	Cell Culture	Mouse
F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-09-15;0(0):. 2020-09-15 [PMID: 32839764] (Bioassay, Human)	Bioassay	Human
J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response bioRxiv, 2020-08-06;0(0):. 2020-08-06 [PMID: 32637964] (Bioassay, Human)	Bioassay	Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
N Chanthra, T Abe, M Miyamoto, K Sekiguchi, C Kwon, Y Hanazono, H Uosaki A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation Sci Rep, 2020-03-06;10(1):4249. 2020-03-06 [PMID: 32144297] (Bioassay, Human)	Bioassay	Human
R Matsumoto, H Suga, T Aoi, H Bando, H Fukuoka, G Iguchi, S Narumi, T Hasegawa, K Muguruma, W Ogawa, Y Takahashi Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells J. Clin. Invest., 2020-02-03;130(2):641-654. 2020-02-03 [PMID: 31845906] (Bioassay, Human)	Bioassay	Human
A Sahabian, M Sgodda, O Naujok, R Dettmer, J Dahlmann, F Manstein, T Cantz, R Zweigerdt, U Martin, R Olmer Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential Cells, 2019-12-04;8(12):. 2019-12-04 [PMID: 31817235] (Bioassay, Human)	Bioassay	Human
W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells Stem Cells, 2019-12-30;0(0):. 2019-12-30 [PMID: 31648393] (Bioassay, Mouse)	Bioassay	Mouse
T Yung, F Poon, M Liang, S Coquenlorg, EC McGaugh, CC Hui, MD Wilson, MC Nostro, TH Kim Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals Nat Commun, 2019-10-11;10(1):4647. 2019-10-11 [PMID: 31604927] (Bioassay, Human)	Bioassay	Human
V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure Nat Commun, 2019-09-24;10(1):4161. 2019-09-24 [PMID: 31551422] (Bioassay, Human)	Bioassay	Human
K Suzuki, M Koyanagi-A, K Uehara, N Hinata, M Fujisawa, T Aoi Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium Sci Rep, 2019-07-19;9(1):10506. 2019-07-19 [PMID: 31324820] (Cell Culture, Human)	Cell Culture	Human
RMJ Genga, EM Kernfeld, KM Parsi, TJ Parsons, MJ Ziller, R Maehr Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development Cell Rep, 2019-04-16;27(3):708-718.e10. 2019-04-16 [PMID: 30995470] (Bioassay, Human)	Bioassay	Human
Y Toba, A Kiso, S Nakamae, F Sakurai, K Takayama, H Mizuguchi FGF signal is not required for hepatoblast differentiation of human iPS cells Sci Rep, 2019-03-06;9(1):3713. 2019-03-06 [PMID: 30842525] (Bioassay, Human)	Bioassay	Human
H Noguchi, C Miyagi-Shi, Y Nakashima, T Kinjo, N Kobayashi, I Saitoh, M Watanabe, AMJ Shapiro, T Kin Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors Mol Ther Methods Clin Dev, 2019-01-29;13(0):243-252. 2019-01-29 [PMID: 30828587] (Bioassay, Human)	Bioassay	Human
C Kumtornrut, T Yamauchi, S Koike, S Aiba, K Yamasaki Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts J. Dermatol. Sci., 2019-01-26;0(0):. 2019-01-26 [PMID: 30792099] (Bioassay, Human)	Bioassay	Human
N Muraoka, K Nara, F Tamura, H Kojima, H Yamakawa, T Sadahiro, K Miyamoto, M Isomi, S Haginiwa, H Tani, S Kurotsu, R Osakabe, S Torii, S Shimizu, H Okano, Y Sugimoto, K Fukuda, M Ieda Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming Nat Commun, 2019-02-20;10(1):674. 2019-02-20 [PMID: 30787297] (Bioassay, Mouse)	Bioassay	Mouse
AJ Miller, BR Dye, D Ferrer-Tor, DR Hill, AW Overeem, LD Shea, JR Spence Generation of lung organoids from human pluripotent stem cells in vitro Nat Protoc, 2019-02-01;14(2):518-540. 2019-02-01 [PMID: 30664680] (Bioassay, Human)	Bioassay	Human
MA Scavuzzo, J Chmielowie, D Yang, K Wamble, LS Chaboub, L Duraine, B Tepe, SM Glasgow, BR Arenkiel, C Brou, B Deneen, M Borowiak Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA Cell Rep, 2018-12-26;25(13):3811-3827.e7. 2018-12-26 [PMID: 30590051] (Bioassay, Mouse)	Bioassay	Mouse
H Chagraoui, MS Kristianse, JP Ruiz, A Serra-Barr, J Richter, E Hall-Ponse, N Gray, D Waithe, K Clark, P Hublitz, E Repapi, G Otto, P Sopp, S Taylor, S Thongjuea, P Vyas, C Porcher SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells Nat Commun, 2018-12-18;9(1):5375. 2018-12-18 [PMID: 30560907] (Bioassay, Human)	Bioassay	Human
TR Broda, KW McCracken, JM Wells Generation of human antral and fundic gastric organoids from pluripotent stem cells Nat Protoc, 2019-01-01;14(1):28-50. 2019-01-01 [PMID: 30470820] (Bioassay, Human)	Bioassay	Human
Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling Cell Stem Cell, 2018-09-20;0(0):. 2018-09-20 [PMID: 30244870] (Bioassay, Human)	Bioassay	Human
JP Ng-Blichfe, A Schrik, RK Kortekaas, JA Noordhoek, IH Heijink, PS Hiemstra, J Stolk, M Königshoff, R Gosens Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation EBioMedicine, 2018-09-17;36(0):461-474. 2018-09-17 [PMID: 30236449] (Bioassay, Human)	Bioassay	Human
R Cruz-Acuña, M Quirós, S Huang, D Siuda, JR Spence, A Nusrat, AJ García PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery Nat Protoc, 2018-09-01;0(0):. 2018-09-01 [PMID: 30190557] (Bioassay, Human)	Bioassay	Human
S Zhang, C Zhao, S Liu, Y Wang, Y Zhao, W Guan, Z Zhu Characteristics and multi?lineage differentiation of bone marrow mesenchymal stem cells derived from the Tibetan mastiff Mol Med Rep, 2018-06-15;0(0):. 2018-06-15 [PMID: 29916546] (Bioassay, Canine)	Bioassay	Canine
H Lahlou, A Lopez-Juar, A Fontbonne, E Nivet, A Zine Modeling human early otic sensory cell development with induced pluripotent stem cells PLoS ONE, 2018-06-14;13(6):e0198954. 2018-06-14 [PMID: 29902227] (Bioassay, Human)	Bioassay	Human
X Guo, Y Xu, Z Wang, Y Wu, J Chen, G Wang, C Lu, W Jia, J Xi, S Zhu, Z Jiapaer, X Wan, Z Liu, S Gao, J Kang A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis Cell Stem Cell, 2018-05-10;0(0):. 2018-05-10 [PMID: 29754779] (Bioassay, Mouse)	Bioassay	Mouse
EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen Beta-Catenin maintains lung epithelial progenitors after lung specification Development, 2018-03-09;0(0):. 2018-03-09 [PMID: 29440304] (Bioassay, Human)	Bioassay	Human
B Memon, M Karam, S Al-Khawaga, EM Abdelalim Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1 Stem Cell Res Ther, 2018-01-23;9(1):15. 2018-01-23 [PMID: 29361979] (Bioassay, Human)	Bioassay	Human
NV Dorrello, BA Guenthart, JD O'Neill, J Kim, K Cunningham, YW Chen, M Biscotti, T Swayne, HM Wobma, SXL Huang, HW Snoeck, M Bacchetta, G Vunjak-Nov Functional vascularized lung grafts for lung bioengineering Sci Adv, 2017-08-30;3(8):e1700521. 2017-08-30 [PMID: 28875163] (Bioassay, Human)	Bioassay	Human
KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors Nat Commun, 2017-08-24;8(1):331. 2017-08-24 [PMID: 28835709] (Bioassay, Human)	Bioassay	Human
AJ Jimenez-Ca, R Pillich, W Yang, GR Diaferia, P Meda, L Crisa, V Cirulli ?E-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation Cell Rep, 2017-08-08;20(6):1295-1306. 2017-08-08 [PMID: 28793255] (Bioassay, Mouse)	Bioassay	Mouse
CR Ball, F Oppel, KR Ehrenberg, TD Dubash, SM Dieter, CM Hoffmann, U Abel, F Herbst, M Koch, J Werner, F Bergmann, N Ishaque, M Schmidt, C von Kalle, C Scholl, S Fröhling, B Brors, W Weichert, J Weitz, H Glimm Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts EMBO Mol Med, 2017-07-01;0(0):. 2017-07-01 [PMID: 28526679] (Bioassay, Human)	Bioassay	Human
E El Agha, V Kheirollah, A Moiseenko, W Seeger, S Bellusci Ex vivo analysis of the contribution of FGF10(+) cells to airway smooth muscle cell formation during early lung development Dev. Dyn., 2017-06-01;0(0):. 2017-06-01 [PMID: 28387977] (Bioassay, Mouse)	Bioassay	Mouse
KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017-03-30;0(0):. 2017-03-30 [PMID: 28366587] (Bioassay, Human)	Bioassay	Human
Z Zhang, K Newton, SK Kummerfeld, J Webster, DS Kirkpatric, L Phu, J Eastham-An, J Liu, WP Lee, J Wu, H Li, MR Junttila, VM Dixit Transcription factor Etv5 is essential for the maintenance of alveolar type II cells Proc. Natl. Acad. Sci. U.S.A, 2017-03-28;0(0):. 2017-03-28 [PMID: 28351980] (Bioassay, Mouse)	Bioassay	Mouse
CE Weeden, Y Chen, SB Ma, Y Hu, G Ramm, KD Sutherland, GK Smyth, ML Asselin-La Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway PLoS Biol, 2017-01-26;15(1):e2000731. 2017-01-26 [PMID: 28125611] (Bioassay, Human)	Bioassay	Human
Retinal Proteoglycans Act as Cellular Receptors for Basement Membrane Assembly to Control Astrocyte Migration and Angiogenesis Cell Rep, 2016-11-08;17(7):1832-1844. 2016-11-08 [PMID: 27829154] (Binding Assay, Mouse)	Binding Assay	Mouse
TGF-?1 promotes acinar to ductal metaplasia of human pancreatic acinar cells Sci Rep, 2016-08-03;6(0):30904. 2016-08-03 [PMID: 27485764] (Bioassay, Human)	Bioassay	Human
Maya Valeska Gozali Photodynamic therapy inhibit Fibroblast Growth Factor-10 induced keratinocyte differentiation and proliferation through ROS in Fibroblast Growth Factor Receptor-2b pathway Sci Rep, 2016-06-07;6(0):27402. 2016-06-07 [PMID: 27273653] (Bioassay, Human)	Bioassay	Human
Yasuhiro Ikeda Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration Stem Cells Transl Med, 2016-03-17;5(5):694-702. 2016-03-17 [PMID: 26987352] (Bioassay, Human)	Bioassay	Human
Comps-Agrar L, Dunshee D, Eaton D, Sonoda J Unliganded fibroblast growth factor receptor 1 forms density-independent dimers. J Biol Chem, 2015-08-13;290(40):24166-77. 2015-08-13 [PMID: 26272615] (Bioassay, Human)	Bioassay	Human
Calderon-Gierszal E, Prins G Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure. PLoS ONE, 2015-07-29;10(7):e0133238. 2015-07-29 [PMID: 26222054] (Bioassay, Human)	Bioassay	Human
Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor A, Yasuda Y, Niki T The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. BMC Cancer, 2015-02-25;15(0):82. 2015-02-25 [PMID: 25884729] (Bioassay, Human)	Bioassay	Human
Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc, 2015-02-05;10(3):413-25. 2015-02-05 [PMID: 25654758] (Bioassay, Human)	Bioassay	Human
Wong , Amy P, Chin , Stephani, Xia , Sunny, Garner , Jodi, Bear , Christin, Rossant , Janet Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nat Protoc, 2015-02-05;10(3):363-81. 2015-02-05 [PMID: 25654755] (Bioassay, Human)	Bioassay	Human
Maass K, Shekhar A, Lu J, Kang G, See F, Kim E, Delgado C, Shen S, Cohen L, Fishman G Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cells. Stem Cells, 2015-04-01;33(4):1102-12. 2015-04-01 [PMID: 25524238] (Bioassay, Mouse)	Bioassay	Mouse
Dalle Nogare D, Somers K, Rao S, Matsuda M, Reichman-Fried M, Raz E, Chitnis A Leading and trailing cells cooperate in collective migration of the zebrafish posterior lateral line primordium. Development, 2014-07-25;141(16):3188-96. 2014-07-25 [PMID: 25063456] (In Vivo, Zebrafish)	In Vivo	Zebrafish
Pethe , Prasad, Nagvenkar , Punam, Bhartiya , Deepa Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. BMC Cell Biol, 2014-05-24;15(0):18. 2014-05-24 [PMID: 24885493] (Bioassay, Human)	Bioassay	Human
Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, Tamada T, Sugiura H, Harigae H, Ichinose M Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10. Mol Cell Biol, 2014-05-27;34(15):2848-56. 2014-05-27 [PMID: 24865969] (Bioassay, Human)	Bioassay	Human
Ohnuma , Kiyoshi, Fujiki , Ayaka, Yanagihara , Kana, Tachikawa , Saoko, Hayashi , Yohei, Ito , Yuzuru, Onuma , Yasuko, Chan , Techuan, Michiue , Tatsuo, Furue , Miho K, Asashima , Makoto Enzyme-free passage of human pluripotent stem cells by controlling divalent cations. Sci Rep, 2014-04-11;4(0):4646. 2014-04-11 [PMID: 24721898] (Bioassay, Human)	Bioassay	Human
Takeuchi , Hiroki, Nakatsuji , Norio, Suemori , Hirofumi Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. Sci Rep, 2014-03-27;4(0):4488. 2014-03-27 [PMID: 24671046] (Bioassay, Human)	Bioassay	Human
Hannan , Nicholas, Fordham , Robert P, Syed , Yasir A, Moignard , Victoria, Berry , Andrew, Bautista , Ruben, Hanley , Neil A, Jensen , Kim B, Vallier , Ludovic Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports, 2013-10-10;1(4):293-306. 2013-10-10 [PMID: 24319665] (Bioassay, Human)	Bioassay	Human
Huang , Sarah X, Islam , Mohammad, O'Neill , John, Hu , Zheng, Yang , Yong-Gua, Chen , Ya-Wen, Mumau , Melanie, Green , Michael, Vunjak-Novakovic , Gordana, Bhattacharya , Jahar, Snoeck , Hans-Wil Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol, 2013-12-01;32(1):84-91. 2013-12-01 [PMID: 24291815] (Bioassay, Human)	Bioassay	Human
Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife, 2013-11-19;2(0):e00940. 2013-11-19 [PMID: 24252877] (Bioassay, Human)	Bioassay	Human
Weedon M, Cebola I, Patch A, Flanagan S, De Franco E, Caswell R, Rodriguez-Segui S, Shaw-Smith C, Cho C, Lango Allen H, Houghton J, Roth C, Chen R, Hussain K, Marsh P, Vallier L, Murray A, Ellard S, Ferrer J, Hattersley A Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nat Genet, 2013-11-10;46(1):61-4. 2013-11-10 [PMID: 24212882] (Bioassay, Human)	Bioassay	Human
Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther, 2012-11-27;21(1):228-39. 2012-11-27 [PMID: 23183535] (Bioassay, Human)	Bioassay	Human
Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev, 2012-02-29;21(12):2273-87. 2012-02-29 [PMID: 22236333] (Bioassay, Mouse)	Bioassay	Mouse
Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant, 2011-12-21;21(6):1321-39. 2011-12-21 [PMID: 22195604] (Cell Culture, Human)	Cell Culture	Human
Patel N, Sharpe PT, Miletich I Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals. Dev. Biol., 2011-07-23;358(1):156-67. 2011-07-23 [PMID: 21806977] (Bioassay, Mouse)	Bioassay	Mouse
Tomlinson DC, Knowles MA Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am. J. Pathol., 2010-10-01;177(5):2379-86. 2010-10-01 [PMID: 20889570] (Bioassay, Human)	Bioassay	Human
Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell, 2009-04-03;4(4):348-58. 2009-04-03 [PMID: 19341624] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J. Biol. Chem., 2008-06-17;283(34):23139-49. 2008-06-17 [PMID: 18559345] (Bioassay, Mouse)	Bioassay	Mouse
Patel VN, Likar KM, Zisman-Rozen S, Cowherd SN, Lassiter KS, Sher I, Yates EA, Turnbull JE, Ron D, Hoffman MP Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. J. Biol. Chem., 2008-01-28;283(14):9308-17. 2008-01-28 [PMID: 18230614] (Bioassay, Mouse)	Bioassay	Mouse
Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem. Biophys. Res. Commun., 2007-12-04;366(1):129-34. 2007-12-04 [PMID: 18060872] (Bioassay, Human)	Bioassay	Human
Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development, 2007-10-24;134(23):4177-86. 2007-10-24 [PMID: 17959718] (Bioassay, Mouse)	Bioassay	Mouse
Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development, 2005-02-16;132(6):1223-34. 2005-02-16 [PMID: 15716343] (Bioassay, Mouse)	Bioassay	Mouse
Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein. Int. J. Dev. Biol., 2003-02-01;47(1):15-29. 2003-02-01 [PMID: 12653248] (In Vivo, Xenopus)	In Vivo	Xenopus
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