TACI/TNFRSF13B/CVID Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TACI, transmembrane activator and CAML-interactor, is a member of the TNF receptor superfamily. TACI is a type III membrane protein with an extracellular
N‑terminus in the absence of a cleaved signal sequence. The extracellular region of TACI contains two cysteine rich domains. Within the TNFRSF, it shares the highest homology with BCMA. TACI and BCMA have both been shown to bind APRIL and BAFF, members of the TNF ligand superfamily. TACI is expressed on the cell surface of B cells and activated, but not resting, T cells. Analogous to BCMA, data suggests that TACI may play an important role in B cell development, function and regulation. Human TACI is a 293 amino acid (aa) protein consisting of a 166 aa extracellular domain, a 20 aa transmembrane domain, and a 107 aa intracellular domain. Human and mouse TACI share 54% amino acid identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: Flow Cytometry, ICC, Immunoprecipitation, Neutralization, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using AF174	Applications	Species
M Imbrechts, K De Samblan, K Fierens, E Brisse, J Vandenhaut, T Mitera, C Libert, I Smets, A Goris, C Wouters, P Matthys IFN-? stimulates CpG-induced IL-10 production in B cells via p38 and JNK signalling pathways Eur. J. Immunol., 2018-08-01;0(0):. 2018-08-01 [PMID: 30004580] (Neutralization, Human)	Neutralization	Human
Saulep-Easton D, Vincent F, Quah P, Wei A, Ting S, Croce C, Tam C, Mackay F The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells. Leukemia, 2015-07-03;30(1):163-72. 2015-07-03 [PMID: 26139429] (Neutralization, Human)	Neutralization	Human
Hoffmann F, Kuhn P, Laurent S, Hauck S, Berer K, Wendlinger S, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister H, Alexander T, Hiepe F, Kumpfel T, Crawford H, Wekerle H, Hohlfeld R, Lichtenthaler S, Meinl E The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. J Immunol, 2014-12-10;194(2):542-52. 2014-12-10 [PMID: 25505277] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Martinez-Gallo M, Radigan L, Almejun M, Martinez-Pomar N, Matamoros N, Cunningham-Rundles C TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes. J Allergy Clin Immunol, 2012-12-11;131(2):468-76. 2012-12-11 [PMID: 23237420] (Flow Cytometry, Human)	Flow Cytometry	Human
He B, Santamaria R, Xu W, Cols M, Chen K, Puga I, Shan M, Xiong H, Bussel JB, Chiu A, Puel A, Reichenbach J, Marodi L, Doffinger R, Vasconcelos J, Issekutz A, Krause J, Davies G, Li X, Grimbacher B, Plebani A, Meffre E, Picard C, Cunningham-Rundles C, Casanova JL, Cerutti A The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat. Immunol., 2010-08-01;11(9):836-45. 2010-08-01 [PMID: 20676093] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Daridon C, Pers JO, Devauchelle V, Martins-Carvalho C, Hutin P, Pennec YL, Saraux A, Youinou P Identification of transitional type II B cells in the salivary glands of patients with Sjogren's syndrome. Arthritis Rheum., 2006-07-01;54(7):2280-8. 2006-07-01 [PMID: 16802367] (ICC, Human)	ICC	Human

Array AF174

• TACI/TNFRSF13B/CVID Antibodies
• TACI/TNFRSF13B/CVID ELISA Kit
• TACI/TNFRSF13B/CVID Lysate
• TACI/TNFRSF13B/CVID Proteins
• TACI/TNFRSF13B/CVID Proteins and Enzymes
• TACI/TNFRSF13B/CVID ELISAs