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Human BAFF/BLyS/TNFSF13B Quantikine ELISA Kit

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Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human BAFF/BLyS/TNFSF13B Quantikine ELISA Kit Summary

Background
The Quantikine Human BAFF/BLyS Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BAFF/BLyS in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human BAFF/BLyS and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human BAFF/BLyS showed linear curves that were parallel to the standard curves obta...ined using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human BAFF.
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Specificity
Natural and recombinant human BAFF/BLyS
Source
N/A
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
TNFSF13B

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using DBLYS0B.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human BAFF/BLyS/TNFSF13B Quantikine ELISA Kit

  • ApoL related ligand TALL-1
  • B lymphocyte stimulator
  • BAFF
  • BAFFB-cell activating factor
  • B-cell-activating factor
  • BLyS
  • BLYSB-lymphocyte stimulator
  • CD257 antigen
  • CD257
  • Dendritic cell-derived TNF-like molecule
  • DTL
  • TALL1
  • TALL-1delta BAFF
  • TALL1Delta4 BAFF
  • THANK
  • TNF- and APOL-related leukocyte expressed ligand 1
  • TNF and ApoL-related leukocyte expressed ligand 1
  • TNF homolog that activates apoptosis
  • TNFSF13B
  • TNFSF20
  • tumor necrosis factor (ligand) superfamily, member 13b
  • tumor necrosis factor (ligand) superfamily, member 20
  • tumor necrosis factor ligand superfamily member 13B
  • tumor necrosis factor superfamily, member 13b
  • tumor necrosis factor-like protein ZTNF4
  • ZTNF4

Background

BAFF (B-cell activating factor), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a TNF superfamily ligand that plays a critical role in the development and survival of B lineage cells. It can be expressed as a homotrimer or as a heteromer in association with the related protein APRIL. It is produced by many hematopoietic cell types, and a soluble form can be released by activated neutrophils. Both BAFF and APRIL signal through the receptors BCMA and TACI, and BAFF additionally signals through BAFF R. Mice that overexpress BAFF exhibit elevated B cell numbers, increased formation and size of germinal centers, and symptoms of autoimmunity. In addition, BAFF costimulates T cell activation, promotes a Th1 biased immune response, and promotes the expansion of Treg cells.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for BAFF/BLyS/TNFSF13B (DBLYS0B)(67)

We have publications tested in 2 confirmed species: Human, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque).


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Human
(66)
Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
(1)
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Showing Publications 1 - 10 of 67. Show All 67 Publications.
Publications using DBLYS0B Applications Species
Lin, J;Deng, W;Liao, J;Ke, D;Cui, L;Zhong, H;Huang, K;Jiang, L;Chen, Q;Xu, F;Tang, F; BAFF deficiency aggravated optic nerve crush-induced retinal ganglion cells damage by regulating apoptosis and neuroinflammation via NF-?B-I?B? signaling International immunopharmacology 2023-12-01 [PMID: 38041956] (Human) Human
Rahmé, Z;Franco, C;Cruciani, C;Pettorossi, F;Zaramella, A;Realdon, S;Iaccarino, L;Frontini, G;Moroni, G;Doria, A;Ghirardello, A;Gatto, M; Characterization of Serum Cytokine Profiles of Patients with Active Lupus Nephritis International journal of molecular sciences 2023-10-04 [PMID: 37834330] (Human) Human
Gyllemark, P;Sjöwall, J;Forsberg, P;Ernerudh, J;Henningsson, AJ; Intrathecal Th17-driven inflammation is associated with prolonged post-treatment convalescence for patients with Lyme neuroborreliosis Scientific reports 2023-06-15 [PMID: 37322136] (Human) Human
R Lievin, H Hendel-Cha, A Baldé, R Lancar, M Algarte-Gé, R Krzysiek, D Costagliol, L Assoumou, Y Taoufik, C Besson Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin Lymphoma Cancers, 2021-12-28;14(1):. 2021-12-28 [PMID: 35008292] (Human) Human
W Alturaiki, A Mubarak, SA Mir, A Afridi, M Premanatha, S Mickymaray, R Vijayakuma, SA Alsagaby, SG Almalki, F Alghofaili, AK Alnemare, BF Flanagan Plasma levels of BAFF and APRIL are elevated in patients with asthma in Saudi Arabia Saudi journal of biological sciences, 2021-08-23;28(12):7455-7459. 2021-08-23 [PMID: 34867050] (Human) Human
X Wang, J Huang, A Zhang, C Fang, Q Ma, P Jiang Altered expression profile of BAFF receptors on peripheral blood B lymphocytes in Graves' disease BMC endocrine disorders, 2021-04-29;21(1):88. 2021-04-29 [PMID: 33926416] (Human) Human
S Sendic, L Mansouri, S Lundberg, A Nopp, SH Jacobson, J Lundahl B cell and monocyte phenotyping: A quick asset to investigate the immune status in patients with IgA nephropathy PLoS ONE, 2021-03-19;16(3):e0248056. 2021-03-19 [PMID: 33740017] (Human) Human
RLI Crake, MR Strother, E Phillips, MP Doogue, M Zhang, CMA Frampton, BA Robinson, MJ Currie Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study Scientific Reports, 2021-03-11;11(1):5648. 2021-03-11 [PMID: 33707475] (Human) Human
C Rönnberg, A Lugaajju, A Nyman, U Hammar, M Bottai, MJ Lautenbach, C Sundling, F Kironde, KEM Persson A longitudinal study of plasma BAFF levels in mothers and their infants in Uganda, and correlations with subsets of B cells PLoS ONE, 2021-01-19;16(1):e0245431. 2021-01-19 [PMID: 33465125] (Human) Human
T Robinson, A Abdelhak, T Bose, E Meinl, M Otto, UK Zettl, R Dersch, H Tumani, S Rauer, A Huss Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis Cells, 2020-11-25;9(12):. 2020-11-25 [PMID: 33255854] (Human) Human
Show All 67 Publications.

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Bioinformatics

Gene Symbol TNFSF13B