SSEA-1 Antibody (MEM-158) [Biotin] Summary
Immunogen |
Human granulocytes |
Localization |
Cell Membrane |
Specificity |
The antibody MEM-158 reacts with CD15, a cell membrane molecule 3-fucosyl-N-acetyllactosamine (3-FAL) strongly expressed on granulocytes, monocytes, macrophages, mast cells; it is also present on Langerhans cells and some myeloid precursors cells. HLDA VI; WS Code AS A053 |
Isotype |
IgM |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
FUT4 |
Purity |
Size Exclusion Chromatography |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Flow Cytometry 1-4 ug/ml
- Immunoprecipitation 1:50
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Readout System |
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Packaging, Storage & Formulations
Storage |
Store at 4C. Do not freeze. |
Buffer |
TBS (approx. pH 8.0) |
Preservative |
0.9% Sodium Azide |
Concentration |
1.0 mg/ml |
Purity |
Size Exclusion Chromatography |
Alternate Names for SSEA-1 Antibody (MEM-158) [Biotin]
Background
CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin's disease.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for CD15/Lewis X Antibody (NB110-81634) (0)
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