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SP-D Antibody (1.7) [DyLight 405]

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Product Details

Summary
Reactivity PoSpecies Glossary
Applications WB, ICC/IF, IHC
Clone
1.7
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-41050AF350
Alexa Fluor 405
NBP1-41050AF405
Alexa Fluor 488
NBP1-41050AF488
Alexa Fluor 532
NBP1-41050AF532
Alexa Fluor 594
NBP1-41050AF594
Alexa Fluor 647
NBP1-41050AF647
Alexa Fluor 700
NBP1-41050AF700
Alexa Fluor 750
NBP1-41050AF750
Biotin
NBP1-41050B
DyLight 350
NBP1-41050UV
DyLight 488
NBP1-41050G
DyLight 550
NBP1-41050R
DyLight 594
NBP1-41050DL594
DyLight 650
NBP1-41050C
DyLight 680
NBP1-41050FR
DyLight 755
NBP1-41050IR
FITC
NBP1-41050F
HRP
NBP1-41050H
Janelia Fluor 549
NBP1-41050JF549
Janelia Fluor 646
NBP1-41050JF646
Unconjugated
NBP1-41050
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-41050
BSA Free
NBP1-41050
BSA Free
NBP1-41050-0.025mg
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SP-D Antibody (1.7) [DyLight 405] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Purified porcine surfactant protein D
Specificity
This antibody detects porcine surfactant protein D (pSP-D), a 138kD member of the collectin family of proteins. Surfactant protein D is thought to play a significant role in the innate immune response against microorganisms within the lungs and at other mucosal surfaces. SP-D is a multifunctional protein which binds selectively to saccharides and lipids on microbial surfaces promoting antimicrobial responses and regulating surfactant lipid homeostasis. SP-D expression is induced in lung surfactant in response to aerogenous bacterial infection, and upon binding to bacteria, promotes phagocytosis and antigen presentation by dendritic cells. Recent studies suggest that pSP-D could serve as a serum biomarker specific for bronchopneumonia in pigs.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SFTPD
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 26092997).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for SP-D Antibody (1.7) [DyLight 405]

  • COLEC7collectin-7
  • Collectin 7
  • Collectin-7
  • Lung surfactant protein D
  • PSPD
  • PSP-D
  • SFTP4
  • SFTP4pulmonary surfactant-associated protein D
  • SFTPD
  • SPD
  • SP-D
  • SP-Dpulmonary surfactant apoprotein
  • surfactant protein D
  • surfactant, pulmonary-associated protein D
  • surfactant-associated protein, pulmonary 4

Background

Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular head regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 88 ng/ml in healthy individuals (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SP-D Antibody
(1.7) [DyLight 405]
NBP1-41050V
SP-D Antibody (1.7) [DyLight 405]
Species: Po
Applications: WB, ICC/IF, IHC

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Bioinformatics

Gene Symbol SFTPD
Entrez
Uniprot